脑苷肌肽联合丁苯酞治疗老年脑梗死患者的效果

Effects of Cerebroside carnosine combined with Butylphthalide in treatment of elderly patients with cerebral infarction

目的:观察脑苷肌肽联合丁苯酞治疗老年脑梗死患者的效果。方法:选取83例老年脑梗死患者作为研究对象,以病历号奇偶数将其分为对照组41例和观察组42例。两组均进行基础治疗,在此基础上,对照组采用丁苯酞氯化钠注射液治疗,观察组采用脑苷肌肽联合丁苯酞氯化钠注射液治疗。比较两组治疗前后神经功能缺损评分、生命质量评分,疗效和不良反应发生率。结果:治疗前,两组美国国立卫生研究院卒中量表(NIHSS)评分和脑卒中专用生活质量量表(SS-QOL)评分比较,差异均无统计学意义(P>0.05);治疗后,两组NIHSS评分均低于治疗前,且观察组低于对照组;两组SS-QOL评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率为93.18%,明显高于对照组的74.42%,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:脑苷肌肽联合丁苯酞治疗老年脑梗死患者可提高治疗总有效率和生命质量评分,以及降低神经功能缺损评分的效果优于单纯丁苯酞治疗效果。

Objective:To explore effect of Cerebroside carnosine combined with Butylphthalide in treatment of elderly patients with cerebral infarction.Methods:83 elderly patients with cerebral infarction were selected as the research objects,and were divided into control group(41 cases)and observation group(42 cases)according to the odd and even numbers of the medical records.Both groups received basic treatment.On this basis,the control group was treated with Butylphthalide and Sodium chloride injection,while the observation group was treated with Cerebroside carnosine combined with Butylphthalide and Sodium chloride injection.The neurological deficits score,quality of life score,efficacy and incidence of adverse reactions were compared between the two groups before and after the treatment.Results:Before the treatment,there were no significant differences between the two groups in the national institutes of health stroke scale(NIHSS)scores and stroke-specific quality of life scale(SS-QOL)scores(P>0.05).After the treatment,the NIHSS scores of the two groups were lower than those before the treatment,and that of the observation group was lower than that of the control group;the SS-QOL scores of the two groups were higher than those before the treatment,and that of the observation group was higher than that of the control group;and the differences were statistically significant(P<0.05).The total effective rate of treatment in the observation group was 93.18%,which was significantly higher than 74.42%in the control group,and the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Cerebroside carnosine and Butylphthalide in the treatment of the elderly patients with cerebral infarction can improve the total effective rate of treatment and the score of quality of life,and reduce the score of neurological deficits.T Moreover,it is superior to single Butylphthalide.