大黄浸泡液灌肠联合早期肠内营养治疗重症急性胰腺炎患者的效果

Effects of Rhubarb soaking solution enema combined with early enteral nutrition in treatment of patients with severe acute pancreatitis

目的:观察大黄浸泡液灌肠联合早期肠内营养治疗重症急性胰腺炎患者的效果。方法:选取76例重症急性胰腺炎患者作为研究对象,按随机数字表法将其分为对照组和观察组各38例。对照组采用早期肠内营养治疗,观察组在对照组基础上联合大黄浸泡液灌肠治疗,比较两组临床疗效、营养指标水平、康复指标水平和并发症发生率。结果:观察组治疗总有效率为97.37%(37/38),高于对照组的78.94%(30/38),差异有统计学意义(P<0.05);治疗后,观察组血清前白蛋白、白蛋白、总蛋白和转铁蛋白水平均高于对照组,差异有统计学意义(P<0.05);观察组腹痛消失时间、腹胀消失时间、住院时间和全身炎症反应综合征缓解时间均短于对照组,差异有统计学意义(P<0.05);观察组并发症发生率为5.26%(2/38),低于对照组的26.32%(10/38),差异有统计学意义(P<0.05)。结论:大黄浸泡液灌肠联合早期肠内营养治疗重症急性胰腺炎患者可提高治疗总有效率和营养指标水平,缩短康复时间,降低并发症发生率,效果优于单纯早期肠内营养治疗。

Objective:To observe effects of Rhubarb soaking solution enema combined with early enteral nutrition in treatment of patients with severe acute pancreatitis.Methods:76 patients with severe acute pancreatitis were selected as the research objects,and were divided into control group and observation group according to the random number table method,38 cases in each.The control group was treated with early enteral nutrition,while the observation group was treated with Rhubarb soaking solution enema on the basis of that of the control group.The clinical efficacy,nutritional index levels,rehabilitation index level and the incidence of complications were compared between the two groups.Results:The effective rate of treatment in the observation group was 97.37%(37/38),which was higher than 78.94%(30/38)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of the serum prealbumin,albumin,total protein and transferrin of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).The disappearance time of abdominal pain and abdominal distension,the hospitalization time,and the systemic inflammatory response syndrome remission time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).The complication rate in the observation group was 5.26%(2/38),which was lower than 26.32%(10/38)in the control group,and the difference was statistically significant(P<0.05).Conclusions:Rhubarb soaking solution enema combined with early enteral nutrition in the treatment of the patients with severe acute pancreatitis can improve the treatment effective rate and the nutritional index levels,shorten the recovery index levels,and reduce the incidence of complications.Moreover,it is superior to single early enteral nutrition therapy.