自噬/苄氯素1调节因子1在自噬与凋亡中作用的研究进展

Research progress on role of autophagy/beclin-1 regulator 1 in autophagy and apoptosis

细胞凋亡(Ⅰ型程序性死亡)和自噬性细胞死亡(Ⅱ型程序性死亡)这2种细胞死亡方式可通过一些蛋白的相互作用而介导形成平衡对立状态。一方面,细胞凋亡由胱天蛋白酶(caspase,CASP)依赖性通路经内源性、外源性或内质网应激诱导途径予以控制,而死亡信号则可经这3种途径介导受损或感染细胞的清除[1-2]。另一方面,细胞自噬由被称为货物受体或自噬受体的特定分子调控,并通过此类受体与特定底物相互作用,介导自噬体形成。

There are complex interactions between autophagy and apoptosis,which can be mediated by specific proteins that play a dual role.Autophagy/beclin-1 regulator 1(AMBRA1)is one of the receptor proteins involved in both autophagy and apoptosis.Recent studies show that AMBRA1 not only interacts with beclin-1,classⅢphosphatidylinositol 3-kinase(PI3KⅢ/VPS34)and a variety of E3 ubiquitin ligases in the cytoplasm to induce autophagy,but also transfers to mitochondria and interacts with microtubule-associated protein 1 light chain 3B(LC3B)to mediate mitophagy.In addition,AMBRA1 is a direct substrate of apoptotic protease(caspase)and its cleavage displays a pro-apoptotic or antiapoptotic activity.This article reviews the role and mechanism of AMBRA1 in regulating autophagy and apoptosis.