青少年吸烟者大脑静息态低频振荡振幅异常研究

青少年吸烟行为与成年后尼古丁成瘾密切相关。针对青少年阶段吸烟展开研究,有助于理解尼古丁成瘾的神经机制。由此,本研究采用低频振荡振幅(amplitude of low-frequency fluctuations,ALFF)方法探讨青少年吸烟者(N=19)较健康非吸烟者(N=25)的大脑局部神经活动的变化异常。结果表明,青少年吸烟者的枕叶(Occipital Lobe)、颞上回(Superior Temporal Gyrus,STG)及额中回(Middle Frontal Gyrus,MFG)区域的ALFF值显著增加;而在颞下回(Inferior Temporal Gyrus,ITG)及额叶肠回(Rectal Gyrus)的ALFF值显著降低(FWE校正,P<0.05)。本实验为探讨尼古丁成瘾的神经机制提供了影像学资料。

People start cigarette smoking at young age is more susceptible to nicotine addiction.Therefore,the elucidation of neural mechanisms underlying cigarette smoking in young smokers might be helpful in the prevention of nicotine addiction.With the application of amplitude of low-frequency fluctuations(ALFF)approach,the current study detected differences of regional neural activity between young smokers and healthy non-smokers.The research results showed that the ALFF values was increased in the occipital lobe,superior temporal gyrus(STG),and middle frontal gyrus(MFG);while decreased ALFF was detected in the inferior temporal gyrus(ITG)and rectal gyrus(P<0.05,FEW corrected).The current findings may provide additional insights of the neural mechanisms of nicotine addiction.