脂联素基因多态性与浙江汉族人群原发性高血压的相关性

Relationship between ADIPOQ polymorphism and essential hypertension in Zhejiang Han population

目的探讨脂联素基因多态性与浙江汉族人群原发性高血压(EH)的相关性。方法选择2018年1月至2019年6月EH患者236例(观察组)和健康体检者256例(对照组),采用竞争性等位基因特异性PCR检测脂联素基因rs1501299和rs2241766位点的基因型和等位基因频率,并结合相关临床指标进行比较。采用logistic回归分析EH的危险因素。结果脂联素基因rs1501299基因型频率在EH组和对照组间分布差异有统计学意义(P<0.05);在显性模型中,观察组rs1501299CC+CA基因型频率高于对照组,差异有统计学意义(P<0.05)。CC+CA基因型男性BMI高于AA基因型(P<0.01)。logistic回归分析显示BMI≥25 kg/m2、rs1501299 CC及CA基因型均是EH的危险因素(均P<0.05)。结论脂联素基因rs1501299多态性可能与浙江汉族人群EH的发病风险相关。

Objective To investigate the correlation between adiponectin gene(ADIPOQ)polymorphism and essential hypertension(EH)in Zhejiang Han population.Methods A total of 236 EH patients and 256 healthy subjects were selected from January 2018 to June 2019.The genotype and allele frequencies of ADIPOQ rs1501299 and rs2241766 were detected using competitive allele specific PCRand compared with relevant clinical indicators.Logistic regression was used to analysis the risk factors of EH.Results Genotypicfrequency of ADIPOQ rs1501299 was significantly different between EH group and control group(P<0.05).In the dominant model,the frequency of rs1501299 CC+CA genotype was significantly higher in EH group than in control group(P<0.05).Body mass index(BMI)was significantly higher in male with CC+CA genotype than with AA genotype(P<0.01).Logistic regression analysis showed that BMI≥25 kg/m2 and rs1501299 CC and CA genotype were risk factors for EH(all P<0.05).Conclusion ADIPOQ rs1501299 polymorphism may be related to EH in Zhejiang Han population.