离子通道及自主神经系统与房室结折返性心动过速关系的研究进展

Research progress on the relationship among ion channels,autonomic nervous system and atrioventricular nodal reentrant tachycardia

房室结折返性心动过速(atrioventricular nodal reentrant tachycardia,AVNRT)是临床上最常见的阵发性室上性心动过速。目前认为房室结双径路或多径路是AVNRT发生的机制,但确切的病理生理机制以及解剖定位至今尚未阐明。近年来,射频消融术治疗AVNRT的成功率可高达95%。分子蛋白的异质性和离子通道的分布差异可能是房室结双径路形成的原因之一。另外,房室结受心外自主神经和心内自主神经的双重支配,自主神经的失衡在AVNRT的诱发与维持中起重要作用。本文主要介绍离子通道及自主神经系统与AVNRT关系的研究进展。

Atrioventricular nodal reentrant tachycardia(AVNRT)is the most common paroxysmal supraventricular tachycardia in clinical practice.At present,dual atrioventricular nodal pathways or multi-pathways are regarded as the matrix of AVNRT,but its exact physiopathologic mechanism and anatomical location have not been elucidated yet.The success rate of radiofrequency ablation can reach as high 95%among AVNRT patients in recent years.The molecular heterogeneity and distributional difference of ion channels may contribute to the formation of dual atrioventricular nodal pathways.In addition,the atrioventricular node is under the dual domination of the extracardiac and intracardiac autonomic nerves;imbalance of autonomic nervous system plays an important role in the induction and maintenance of AVNRT.This paper mainly introduces the research advances in the relationship among ion channels,autonomic nervous system and AVNRT.