克林霉素对生殖道B族链球菌感染孕妇胎膜早破及母婴结局的影响

Effects of Clindamycin on Premature Rupture of Membranes and Maternal and Infant Outcomesin Pregnant Women with Genital Tract Group B Streptococcus Infection

目的:研究克林霉素对生殖道B族链球菌感染孕妇胎膜早破及母婴结局的影响。方法:选择2019年1月—2019年8月本院收治的80例生殖道B族链球菌感染患者为研究对象,采用随机数表法分为两组各40例。对照组给予常规产科分娩期干预,观察组在对照组基础上给予克林霉素抗感染治疗。比较两组临床指标、胎膜早破、母婴不良结局、妊娠结局、分娩方式等情况。结果:观察组住院时间、住院费用均低于对照组,新生儿出生1 min、5 min Apgar评分高于对照组,差异均有统计学意义(P<0.05);观察组胎膜早破、宫内感染、新生儿感染、产褥感染发生率均低于对照组,差异有统计学意义(P<0.05);观察组早产率、流产率均低于对照组,自然分娩率高于对照组,差异有统计学意义(P<0.05)。结论:生殖道B族链球菌感染孕妇采用克林霉素抗感染治疗效果较好,可有效减少胎膜早破发生,降低早产、流产率,改善分娩不良结果,母婴结局较好。

Objective:To investigate the effects of clindamycin on premature rupture of membranes and maternal and infant outcomes in pregnant women with genital tract group B streptococcus infection.Methods:80 patients with genital tract group B streptococci infection treated in our hospital from January 2019 to August 2019 were selected as the research subjects,the random number table method was used to divide them into two groups,40 cases in each group.The control group was given routine obstetric intervention during delivery,the observation group was given clindamycin anti-infection treatment on the basis of the control group,the clinical indexes,premature rupture of membranes,adverse maternal and infant outcomes,pregnancy outcomes and delivery methods were compared between the two groups.Results:The hospitalization time and cost of the observation group were lower than those of the control group,and the newborn was born within 1 min and 5 min Apgar score was higher than the control group,the differences were statistically significant(P<0.05);the incidence of premature rupture of membranes,intrauterine infection,neonatal infection,puerperal infection in the observation group were lower than the control group,the differences were statistically significant(P<0.05);the preterm birth rate and abortion rate in the observation group were lower than those in the control group,the natural delivery rate was higher than that in the control group,the differences were statistically significant(P<0.05).Conclusion:Clindamycin is effective in the treatment of group B streptococcus infection in pregnant women,which can effectively reduce the incidence of premature rupture of membranes,reduce the rate of premature delivery and abortion,improve the poor delivery results,and improve the maternal and infant outcomes.