期刊文献+

子痫前期孕妇外周血和脐血锰与早产的关系 被引量:1

Relationship between peripheral blood and cord blood manganese levels and preterm delivery in pregnant women with preeclampsia
下载PDF
导出
摘要 目的了解子痫前期和非妊娠期高血压疾病孕妇外周血和脐血锰(Mn)不同水平时早产的发生情况,探讨孕妇外周血和脐血Mn对早产的影响。方法以山西医科大学第一医院产科分娩的427对子痫前期和非妊娠期高血压疾病孕妇为研究对象,收集孕妇一般情况、妊娠和分娩情况等,采集孕妇外周血和脐血进行Mn质量浓度的电感耦合等离子体质谱法(ICP-MS)测定,妊娠满28周不足37周分娩者为早产。结果子痫前期孕妇新生儿脐血Mn低水平(<44.598μg/L)、中水平(44.598~65.966μg/L)和高水平(≥65.967μg/L)时早产发生比例分别为32.11%(35/109)、43.24%(64/148)和49.41%(84/170)(χ2=8.13,P=0.0171);晚发子痫前期孕妇新生儿脐血Mn低、中和高水平时早产的比例分别为14.49%(10/69)、21.84%(19/87)和32.95%(29/88)(χ2=7.55,P=0.0229)。控制了潜在的混杂因素等后,与脐血Mn低水平相比,子痫前期孕妇[(OR=2.27,95%CI:(1.23,4.17)]和晚发子痫前期孕妇[(OR=3.17,95%CI:(1.09,9.23)]脐血Mn高水平时发生早产的危险高。结论子痫前期孕妇脐血锰水平偏高与早产的发生有关。 Objective To determine the incidence of preterm delivery in pregnant women with different levels of peripheral blood and cord blood manganese and diagnosed with preeclampsia and non-pregnancy hypertension,and to investigate the effects of peripheral blood and cord blood manganese levels on preterm delivery.Methods A total of 427 pregnant women with preeclampsia and non-pregnancy hypertension admitted to the Department of Obstetrics,First Hospital of Shanxi Medical University,were included as the subjects in the study.The general conditions,pregnancy and childbirth of the pregnant women were collected.Peripheral blood and cord blood of pregnant women were collected for inductively coupled plasma mass spectrometry(ICP-MS)of Mn mass concentration.Those who gave birth over 28 weeks but less than 37 weeks were considered as premature.Results In the preeclampsia pregnant women with low(<44.598μg/L),medium(44.598-65.966μg/L)and high(≥65.967μg/L)Mn level in cord blood,the prevalences of preterm delivery were 32.11%(35/109),43.24%(64/148)and 49.41%(84/170),respectively(χ2=8.13,P=0.0171).In the late-onset preeclampsia pregnant women with low,medium and high Mn level in cord blood,the prevalences of preterm delivery were 14.49%(10/69),21.84%(19/87),and 32.95%(29/88),respectively(χ2=7.55,P=0.0229).After controlling for potential confounders,the risk of preterm delivery was high in preeclampsia pregnant women[OR=2.27,95%CI:(1.23,4.17)]and late-onset preeclampsia pregnant women(OR=3.17,95%CI:1.09,9.23)with high cord blood Mn level compared with those with low cord blood Mn level.Conclusion High cord blood Mn level in pregnant women with preeclampsia is related to the occurrence of preterm delivery.
作者 高林英 王颖 邬惟为 冯永亮 杨海澜 王素萍 Gao Linying;Wang Ying;Wu Weiwei;Feng Yongliang;Yang Hailan;Wang Suping(Department of School of Public Health,Shanxi Medical University,Taiyuan 030001,China)
出处 《中国药物与临床》 CAS 2021年第2期185-188,共4页 Chinese Remedies & Clinics
基金 国家自然科学基金(81703314) 山西医科大学博士启动基金(03201615)。
关键词 子痫前期 早产 孕妇 脐血 Preeclampsia Manganese Premature delivery Pregnant women Cord blood
  • 相关文献

参考文献5

二级参考文献56

共引文献54

同被引文献12

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部