MicroRNA-152在妇科生殖道恶性肿瘤中的研究进展

Research progress of microRNA-152 in gynecological genital malignant tumors

MicroRNA(miRNA)是一类长度约为19~25个核苷酸参与转录后基因调控的内源性染色体上非编码的单链小RNA分子,它们广泛存在于植物、动物及病毒中。miRNA数量庞大,并且其生物学功能非常复杂,许多miRNA在恶性肿瘤的进展中发挥促癌或者抑癌的作用。MicroRNA-152(miR-152)是近年来较受关注的miRNA之一,在许多恶性肿瘤中充当抑癌因子,在妇科三大生殖道恶性肿瘤:子宫内膜癌、卵巢癌和宫颈癌中表达水平显著降低,现就miR-152与三者之间的研究现状进行综述。

MicroRNAs are a class of non-coding single-stranded small RNA molecules that are about 19-25 nucleotides in length and are involved in the regulation of post-transcriptional levels of genes.They are widely found in plants,animals and viruses.The number of miRNAs is large,and their biological functions are very complex.Many miRNAs play a role in promoting or suppressing cancer in the progression of malignant tumors.MicroRNA-152 is one of the more closely concerned miRNAs in recent years.It acts as a tumor suppressor in many malignant tumors.It is significantly reduced in the three major genital malignant tumors of gynecology:endometrial cancer,ovarian cancer and cervical cancer.Now we review the current research status between miR-152 and the three major genital malignant tumors of gynecology.