阿司匹林联合他汀类药物对脑血栓患者动脉斑块的改善及神经功能的影响

Effect of aspirin combined with statins on the improvement of arterial plaque and nerve function in patients with cerebral thrombosis

目的探讨阿司匹林联合他汀类药物对脑血栓患者动脉斑块和神经功能的临床作用。方法2016年1月~2017年6月在本院纳入100例脑血栓病情稳定期的患者,按照随机数字表法分成两组,每组各50例。对照组予阿司匹林药物方案治疗,观察组予阿司匹林+阿托伐他汀钙的联合药物方案治疗。比较两组治疗前后的颈动脉斑块面积及颈动脉中层厚度,美国国立卫生院神经功能缺损评分(National Institutes of Health Stroke Scale,NIHSS),自我能力评分(Activities of daily living scale,ADL)、临床总有效率。结果治疗后观察组颈动脉斑块面积为(1.42±0.27)cm2,动脉内膜中层厚度为(0.67±0.12)mm,NIHSS评分为(11.30±2.27)分,ADL评分为(81.34±7.35)分,如上指标的改善均优于对照组[分别是(1.68±0.34)cm2、(0.75±0.20)mm、(14.75±3.64)分、(66.40±5.77)分],两组比较,差异有统计学意义(均P<0.05)。观察组的总有效率为90.0%,对照组为75.0%,两组临床疗效比较,差异有统计学意义(P=0.001)。结论阿司匹林联合他汀类联合药物方案治疗脑血栓具有更优的临床疗效,可降低颈动脉斑块面积及颈动脉中层厚度,更好地改善神经功能,提高患者的自我生活能力。

Objective To explore the clinical effect of aspirin combined with statins on arterial plaque and nerve function in patients with cerebral thrombosis.Methods A total of 100 patients with stable cerebral thrombosis from January 2016 to June 2017 in this hospital were enrolled and divided into two groups according to the random number table method,with 50 cases in each group.The control group was treated with aspirin medication,and the observation group was treated with aspirin+atorvastatin calcium.The carotid artery plaque area and the carotid artery median thickness,the National Institutes of Health Stroke Scale(NIHSS),the Activity of daily living scale(ADL),and the total clinical efficiency before and after treatment between the two groups were compared.Results After treatment,the carotid artery plaque area(1.42±0.27)cm2,the arterial intima-media thickness(0.67±0.12)mm,the NIHSS score(11.30±2.27),and the ADL score(81.34±7.35)in the observation group were better than those of the control group[(1.68±0.34)cm2,(0.75±0.20)mm,(14.75±3.64)points,(66.40±5.77)points].The difference between the two groups was statistically significant(all P<0.05).The observation group's total effective rate was 90.0%,and that of the control group was 75.0%.The difference in clinical efficacy between the two groups was statistically significant(P=0.001).Conclusion The combination of aspirin and statins has a better clinical effect in the treatment of cerebral thrombosis,which can reduce the carotid plaque area and the thickness of the carotid artery,better improve the nerve function,and improve the patient's self-life ability.