二甲双胍在肿瘤治疗中的研究进展

Research progress of metformin in tumor therapy

目的综述二甲双胍在肿瘤治疗中的作用机制与最新进展。方法通过搜索“二甲双胍”“抗肿瘤”“作用机制”等关键词,运用SciFinder、Elsevier、Web of Science、中国知网、万方等数据库,查阅了相关文献,并对其进行了归纳、分析和总结。结果二甲双胍有多种潜在的抗肿瘤作用机制,对乳腺癌、卵巢癌、前列腺癌和肝癌等都具有明显的抑制作用。结论二甲双胍的抗肿瘤作用具有广阔的研究前景,可以为癌症治疗提供新的治疗方案与思路。

Objective To review the mechanism and latest progress of metformin in cancer treatment.Methods By searching for keywords such as“metformin”,“anti-tumor”,“mechanism of action”,etc.,using SciFinder,Elsevier,Web of Science,CNKI,WanFang Data and other databases,we read and reviewed the relevant literatures and carried out induction,analysis and summary.Results Metformin has a variety of potential anti-tumor mechanisms,and it has obvious inhibitory effects on different kinds of cancer such as breast cancer,ovarian cancer,prostate cancer and liver cancer.Conclusions The antitumor effect of metformin has broad research prospects and can provide new treatment options and ideas for cancer treatment.