不同剂量右美托咪定麻醉对食管癌根治术患者术后认知功能的影响

Effect of Different Doses of Dexmedetomidine Anesthesia on Postoperative Cognitive Function in Patients with Esophageal Cancer after Radical Operation

目的探讨不同剂量右美托咪定麻醉对食管癌根治术患者术后认知功能的影响。方法随机选取2017年1月至2019年1月在我院接受治疗的120例食管癌根治术患者作为研究样本,将其随机分为低剂量组(n=40)与高剂量组(n=40)及对照组(n=40),低剂量组采用低剂量的右美托咪定进行麻醉,高剂量组采用高剂量右美托咪定进行麻醉,对照组采用常规的生理盐水进行空白对照。对比3组患者的生活质量和术前及术后3、6、8 d的认知功能。结果高剂量组患者的生活质量评分均高于低剂量组与对照组,3组数据之间对比差异有统计学意义(P<0.05)。3组患者术前的认知功能评分对比,差异无统计学意义(P>0.05);高剂量组术后3、6、8 d的认知功能评分明显高于低剂量组与对照组,差异有统计学意义(P<0.05)。结论在食管癌根治术中采用准确剂量的麻醉诱导有非常显著的效果,可有效降低术后疼痛程度,促进术后认知功能的提升。

Objective To investigate the effect of different doses of dexmedetomidine anesthesia on postoperative cognitive function in patients with esophageal cancer after radical operation.Methods From January 2017 to January 2019,120 patients with radical esophagectomy in our hospital were randomly divided into low-dose group(n=40),high-dose group(n=40)and control group(n=40)as the research samples.The lowdose group was anesthetized with low-dose dexmedetomidine,the high-dose group was anesthetized with high-dose dexmedetomidine,and the control group was given normal saline was used for anesthesia.The general quality of life score and cognitive function score of 3 days,6 days and 8 days before and after operation were compared among the three groups.Results The general quality of life score of the high-dose group was higher than that of the low-dose group and the control group,and the difference between the three groups was statistically significant(P<0.05).Three groups of patients with preoperative cognitive function score comparison,data difference was large(P>0.05),no statistical significance.The cognitive function scores of the high-dose group at 3 days,6 days and 8 days after operation were significantly higher than those of the lowdose group and the control group(P<0.05).Conclusion Radical esophagectomy was a kind of common operation with large trauma.The correct dose of anesthesia induction has a very significant effect in clinical practice,which can effectively reduce the postoperative pain of patients and promote the rising trend of postoperative cognitive function.