摘要
目的观察下肢动脉硬化闭塞症患者(ASO)应用自制通脉膏治疗后的临床效果,并探讨其作用机制。方法选择2018年1月至2019年3月我院收治的80例Ⅱ期ASO患者,随机分成A、B两组,各40例。A组给予自制通脉膏15 g,冲服,每日2次。B组给予通塞脉片,每日3次,每次6片,口服。1个疗程为40 d,两组均治疗2个疗程。比较两组疗效。结果A组患者治疗总有效率比B组高,差异有显著性(P<0.05)。A、B两组ABI指数治疗前后比较有显著性差异(P<0.05)。A组患者CHOL、LDL、TG、HDL、IMT、TNUT、SNUT治疗前后比较有显著性差异(P<0.05),B组患者CHOL、TG治疗前后比较有显著性差异(P<0.05),B组HDL、LDL、IMT、TNUT、SNUT治疗前后比较差异无统计学意义(P>0.05)。结论与通塞脉片相比,自制通脉膏治疗下肢动脉硬化闭塞症疗效更满意,具有调血脂、消斑块、通血管、改善血供等作用。
Objective To observe the clinical effects of patients with lower extremity arteriosclerosis obliterans(ASO)after applying self-made tongmai ointment,and to explore its mechanism of action.Methods A total of 80 patients with stage II ASO admitted to our hospital from January 2018 to March 2019 were selected and randomly divided into two groups A and group B,with 40 cases in each group.Group A was given 15 g of self-made tongmai ointment,which was taken twice a day.Group B was given tongsaimai tablets 3 times a day,6 tablets each time,orally.One course of treatment was 40 days,and both groups were treated for 2 courses.The efficacy of the two groups was compared.Results The total effective rate of treatment in group A was higher than that in group B,and the difference was significant(P<0.05).The ABI index of the two groups A and group B were significantly different before and after treatment(P<0.05).There were significant differences before and after treatment with CHOL,LDL,TG,HDL,IMT,TNUT,and SNUT in group A(P<0.05),group B patients had significant differences before and after treatment with CHOL and TG(P<0.05),group B HDL,LDL,IMT,TNUT,SNUT had no significant difference before and after treatment(P>0.05).Conclusion Compared with tongsaimai tablets,self-made tongmai ointment was more effective in treating lower extremity arteriosclerosis obliterans,and has the effects of regulating blood lipids,eliminating plaques,venting blood vessels,and improving blood supply.
作者
吴建华
张汉超
王轶
王海青
鞠振国
WU Jianhua;ZHANG Hanchao;WANG Yi;WANG Haiqing;JU Zhenguo(Xuzhou Hospital of Traditional Chinese Medicine,Xuzhou 221003,China)
出处
《中国医药指南》
2020年第36期147-149,共3页
Guide of China Medicine
基金
2019年徐州市推动科技创新项目(编号KC19171)。
关键词
下肢动脉硬化闭塞症
中医药疗法
自制煎膏剂
通脉膏
Arteriosclerosis obliterans of lower extremity
Therapy of traditional Chinese medicine
Self-made decoction paste
Tongmai ointment