胃力康颗粒对胃溃疡大鼠炎性因子表达的影响

Effect of Welikang on the Expression of inflammatory factors in Rat with Gastric Ulcer

目的:初步探讨胃力康颗粒对胃溃疡大鼠IL-6、IL-8表达水平的影响。方法:实验大鼠随机分成正常组、模型组、治疗组、对照组。Okabe改良法复制实验性胃溃疡模型,治疗组给予胃力康颗粒灌胃,对照组给予法莫替丁灌胃,疗程共14 d。ELISA法检测各组大鼠血清IL-6与IL-8含量的变化。结果:模型组大鼠血清IL-6、IL-8水平与正常组比较明显升高,差异有统计学意义(P<0.05);治疗组和对照组较模型组明显降低大鼠血清IL-6、IL-8,差异有统计学意义(P<0.05),胃溃疡面积亦明显减小,差异有统计学意义(P<0.05)。结论:胃力康颗粒可以降低溃疡大鼠血清IL-6与IL-8水平,发挥保护胃黏膜的作用。

Objective To investigate the curative mechanism of Welikang and the effect of Welikang on the expression of IL-6 and IL-8 in gastric mucosa in rat with experimental gastric ulcer.Method The rats were randomly divided into normal group model group,treatment group and control group.The treatment group was given weilikang granules by gavage,and the control group was given famotidine by gavage.The course of treatment was 14 days,and the expression of IL-6 and IL-8 in the mucosa was measured by ELISA.Results The content of IL-6 and IL-8 in the model group were significantly higher than those in the normal group(P<0.05);The content of IL-6 and IL-8 in the treatment group and the coutrol group were significantly lower than those in the maodel group(P<0.05),and the area of gastric ulcer was also significantly reduced(P<0.05).Conclusion Welikang can decrease the content of IL-6 and IL-8 in serum,which may be the one basis of the mechanism to accelerate ulcer healing.