前列地尔联合替格瑞洛治疗老年不稳定型心绞痛的有效性与安全性分析

Clinical efficacy and safety of alprostadil combined with ticagrelor in the treatment of elderly patients with unstable angina

目的:探讨前列地尔联合替格瑞洛治疗老年不稳定型心绞痛的有效性和安全性。方法:选择老年不稳定型心绞痛患者100例,将其随机分为对照组和治疗组,各50例。对照组给予不稳定型心绞痛常规治疗,双抗采用拜阿司匹林加替格瑞洛。治疗组也给予常规治疗,并在其基础上加用前列地尔,分析比较两组患者治疗前后治疗有效性、发作频率、持续时间、住院日、症状缓解时间、心脏彩超指标变化。结果:对照组治疗后心功能、发作频率、持续时间均得到明显改善,差异有统计学意义(P<0.05);治疗组疗效显著,心功能、发作频率、持续时间、住院日及症状缓解时间等各项指标均得到明显改善,且与对照组差异均有统计学意义(P<0.05);对照组和治疗组均有出血事件发生,但以轻度出血为主,组间差异无统计学意义(P>0.05)。结论:前列地尔联合替格瑞洛治疗老年不稳定型心绞痛的疗效显著,且不增加其出血风险,具有较高安全性。

Objective To observe the therapeutic effect and safety of alprostadil combined with ticagrelor in elderly patients with unstable angina.Method One hundred patients with unstable angina were randomly divided into two groups,the control group(n=50),the treatment group(n=50).The alprostadil plus ticagrelor were given based on the routine treatment in patients of treatment group,the control group took routine treatment.The changes before and after treatment were compared.Results The heart function,frequency and duration in control group was improved after treatment(P<0.05),in treatment group parameters including clinical effectiveness,left ventricular ejection fraction,frequency,duration and hospital stay were improved significantly(P<0.05).The rate of bleeding in the control group and treatment group was not statistically significant(P>0.05).Conclusion Alprostadil combined with ticagrelor is significantly effective in the treatment of elderly patients with unstable angina,and do not increase the risk of bleeding.