溃疡性结肠炎合并非酒精性脂肪肝的临床特征及危险因素分析

Clinical features and risk factors of ulcerative colitis complicated with non-alcoholic fatty liver disease

目的分析溃疡性结肠炎(UC)合并非酒精性脂肪肝(NAFLD)患者的临床特征及危险因素。方法选择2018年10月~2020年3月于潍坊市人民医院诊断为UC的住院患者159例,根据是否合并NAFLD分为NAFLD组(n=42)与对照组(n=117),回顾性分析两组患者临床特征及实验室检查的差异,并采用多因素回归法分析UC发生NAFLD的危险因素。结果159例UC患者NAFLD的发生率为26.42%,在年龄、性别、吸烟史、冠心病、是否应用激素、病变范围、Mayo评分、GGT、WBC、PLT、Hb、CRP、HDL、TG方面,NAFLD组与对照组比较差异均无统计学意义(P>0.05),在糖尿病、高血压、AST、ALT、ESR、CHOL方面,NAFLD组与对照组比较差异有统计学意义(P<0.05)。将糖尿病、高血压、AST、ALT、ESR、CHOL进一步纳入多因素分析,结果显示合并糖尿病[OR=3.419,95%CI(1.494,23.642)]、高AST[OR=1.086,95%CI(1.001,1.177)]、高ALT[OR=1.070,95%CI(1.017,1.125)]是UC发生NAFLD的危险因素。结论合并糖尿病、高AST、高ALT是UC发生NAFLD的危险因素。

Objective To analyze the clinical characteristics and risk factors of ulcerative colitis(UC)complicated with non-alcoholic fatty liver disease(NAFLD).Methods A total of 159 hospitalized patients with UC in Weifang People’s Hospital from Oct 2018 to Mar 2020 were included in the retrospective study.Patients were divided into NAFLD group(with NAFLD,n=42)and the control group(without NAFLD,n=117).The differences of clinical characteristics and laboratory examination between the two groups were analyzed and compared.The risk factors of NAFLD in UC were analyzed by logistic regression analysis.Results The incidence of NAFLD in 159 patients with UC was 26.42%.univariate analysis in age,gender,smoking history,coronary heart disease,hormonotherapy,localization,Mayo score,GGT,WBC,PLT,Hb,CRP,HDL,TG showed no significantly difference(P>0.05)between two groups,but there were significant differences in diabetes,hypertension,AST,ALT,ESR,CHOL between two groups(P<0.05).Diabetes,hypertension,AST,ALT,ESR and CHOL were further included in the multivariate analysis.The results showed that diabetes[OR=3.419,95%CI(1.494,23.642)],AST[OR=1.086,95%CI(1.001,1.177)],ALT[OR=1.070,95%CI(1.017,1.125)]were the risk factors of NAFLD with UC.Conclusion Diabetes,high AST and high ALT are the risk factors of NAFLD in UC.