重症甲型流感诱发急性肺损伤的可能机制及治疗进展

The progress of possible mechanism and treatment of severe acute lung injury induced by influenza A virus

甲型流感是一种急性传染性呼吸道疾病,通常表现为上呼吸道和/或下呼吸道受累的体征和症状,以及全身性疾病(如发烧、头痛、肌痛和乏力)的症状。尽管它在一般人群中是一种自限性感染,但它与某些高风险人群的发病率和病死率增加相关;并且通常存在着严重的并发症,如严重的急性肺损伤、急性呼吸窘迫综合征以及其他肺外损伤。针对甲型流感肺部损伤机制的探讨有助于了解其他病毒性肺炎的致病机制,如新型冠状病毒肺炎。

Influenza A is an acute infectious respiratory disease caused by influenza A virus,with typical signs and symptoms of upper and/or lower respiratory tract involvement,and symptoms of systemic disease such as fever,headache,myalgia and fatigue.Although it is a self-limited disease in the general population,it is associated with increased morbidity and mortality in some high-risk populations and often leads serious complications,such as severe acute lung injury,acute respiratory distress syndrome,as well as other extrapulmonary injuries.The exploration of the mechanisms of lung injury caused by influenza A infection could be helpful to understand the pathogenic mechanisms of other viral pneumonias,such as coronavirus disease 2019.