非编码RNA在肺纤维化中作用机制的研究进展

Research progress on the mechanism of non-coding RNA in pulmonary fibrosis

肺纤维化是一类可由多种原因引起的、慢性、纤维化性肺疾病,主要病理特征是正常肺组织结构破坏后的过度瘢痕修复,最终导致呼吸功能不全。虽然有关肺纤维化病理生理机制的研究已取得较大进展,但其发病机制尚未完全阐明,临床上仍是无法治愈的。近年来,研究发现非编码RNA(non-coding RNA,ncRNA)在肺纤维中发挥了重要作用,因此该文总结了ncRNA通过影响上皮-间质转化、肺成纤维细胞的活化及巨噬细胞的功能进而调控肺纤维化的相关进展,以期为肺纤维化的治疗提供新思路。

Pulmonary fibrosis is a kind of chronic and fibrotic lung disease caused by a variety of reasons,and its main pathological characteristic is excessive scar formation after the destruction of normal lung tissue structure,which eventually leads to respiratory insufficiency.Although the research on the pathophysiological mechanism of pulmonary fibrosis has made great progress,its pathogenesis has not been fully elucidated,and it is still clinically incurable.In recent years,studies have shown that non-coding RNAs are involved in the pathogenesis of pulmonary fibrosis,therefore,this article summarizes the related research progress of non-coding RNA in regulation of pulmonary fibrosis by affecting epithelial-mesenchymal transition,fibroblast activation and function of macrophages,in order to provide new ideas for the treatment of pulmonary fibrosis.