玻璃体腔注射雷珠单抗对视网膜静脉阻塞眼部血流动力学的影响

Effect of intravitreal ranibizumab injection on ocular hemodynamics in retinal vein occlusion

目的探讨单眼玻璃体腔注射雷珠单抗治疗视网膜静脉阻塞短期内对眼球后血管血流动力学的影响。方法本研究为前瞻性介入性临床研究,纳入确诊为视网膜静脉阻塞继发黄斑水肿的患者,在玻璃体腔注射雷珠单抗前和注射后1周,应用彩色多普勒显像测量注射眼和对侧眼的眼动脉、视网膜中央动脉和睫状体后动脉的血流动力学参数,包括收缩峰值流速、舒张末期流速和阻力指数。结果玻璃体腔注射雷珠单抗显著降低了注射眼视网膜中央动脉和睫状后短动脉的收缩峰值流速和舒张末期流速,并显著提高了阻力指数(P<0.05)。注射后,注射眼与未注射眼在视网膜中央动脉和睫状后短动脉的收缩峰值流速、舒张末期流速和阻力指数上差异均有统计学意义(P<0.05)。结论玻璃体腔注射雷珠单抗会短时间内改变视网膜静脉阻塞继发黄斑水肿患者注射眼的眼部血流速度。

Objective To investigate the short-term effect of single intravitreal ranibizumab injection on retrobulbar blood flow in patients with retinal vein occlusion. Methods In this prospective interventional study, patients with macular edema secondary to retinal vein occlusion were included. The hemodynamic parameters of the ophthalmic artery, central retinal artery and posteriorciliary artery comprising peak systolicvelocity, end-diastolic velocity, and resistive index were measured by using color doppler imaging in both injected and uninjected fellow eyes at baseline and one week after the injection. Results Intravitreal ranibizumab induced a significant reduction in the peak systolic velocity and end-diastolic velocity and a significant rise in the resistive index of the central retinal artery and short posterior ciliary artery of the injected eye. After injection, there was any significant difference between injected and uninjected eyes in the peak systolic velocity,end-diastolic velocity,and resistive index values of central retinal artery and short posterior ciliary artery. Conclusion In patients with macular edema secondary to retinal vein occlusion,intravitreal injection of ranibizumab alters retrobulbar blood flow velocities in injected eyes in the short-term period.