NT-proBNP、CysC与高血压心力衰竭患者疾病严重程度及预后的相关性研究

Study on the Correlation between NT-proBNP,CysC and Disease Severity and Prognosis in Patients with Hypertensive Heart Failure

目的探讨N末端脑钠肽前体(NT-proBNP)、胱抑素C(CysC)与高血压心力衰竭患者疾病严重程度及预后的相关性。方法回顾性分析2017年1月至2020年2月我院收治的82例高血压心力衰竭患者的临床资料,比较不同心功能分级、不同预后高血压心力衰竭患者的N T-proBNP、CysC及心功能指标,分析高血压心力衰竭患者NT-proBNP、CysC与心功能的相关性。结果随着NYHA心功能分级升高,患者的NT-proBNP、CysC、LVEDd明显升高,LVEF明显降低(P<0.05)。死亡患者的NT-proBNP、CysC、LVEDd高于生存患者,LVEF低于生存患者(P<0.05)。高血压心力衰竭患者的N T-proBNP、CysC与LVEDd呈正相关,与LVEF呈负相关(P<0.05)。结论N T-proBNP、CysC水平越高,则高血压心力衰竭患者病情越严重、预后越差,可将其作为评估高血压心力衰竭患者病情严重程度和预测预后的重要指标。

Objective To explore the correlation between N-terminal pro-brain natriuretic peptide(NT-proBNP),cystatin C(CysC)and disease severity and prognosis in patients with hypertensive heart failure.Methods The clinical data of 82 patients with hypertensive heart failure admitted to our hospital from January 2017 to February 2020 were retrospectively analyzed.The NT-proBNP,CysC and heart function indicators of hypertensive heart failure patients with different heart function grades and different prognosis were compared.The correlation between NT-proBNP,CysC and heart function in patients with hypertensive heart failure was analyzed.Results With the increase of NYHA heart function grade,the NT-proBNP,CysC and LVEDd increased significantly,and the LVEF decreased significantly(P<0.05).The NT-proBNP,CysC and LVEDd of the dead patients were higher than those of the survival patients,and the LVEF was lower than that of the survival patients(_P<0.05).The NT-proBNP and CysC were positively correlated with LVEDd,and negatively correlated with LVEF in patients with hypertensive heart failure(P<0.05).Conclusions The higher the NT-proBNP and CysC,the more severe the condition of patients with hypertensive heart failure and the worse the prognosis.They can be used as important indicators to assess the severity of patients with hypertensive heart failure,and predict the prognosis.