西那卡塞联合小剂量骨化三醇治疗重度继发性甲状旁腺功能亢进的效果及其对骨代谢的影响

Effect of Cinacalcet Combined with Low-Dose Calcitriol in the Treatment of Severe Secondary Hyperparathyroidism and the Influence on Bone Metabolism

目的探讨西那卡塞联合小剂量骨化三醇治疗重度继发性甲状旁腺功能亢进的效果及其对骨代谢的影响。方法选取我院收治的80例重度继发性甲状旁腺功能亢进患者,随机分为观察组与对照组各40例,对照组单纯使用西那卡塞治疗,观察组采用西那卡塞联合小剂量骨化三醇治疗,对比两组的治疗效果。结果观察组的治疗总有效率为92.50%,高于对照组的75.00%(P<0.05)。治疗后,两组的ALP、OC及β-cross水平均降低,且观察组的ALP、OC及β-cross水平低于对照组(P<0.05)。观察组的不良反应发生率为5.00%,低于对照组的20.00%(P<0.05)。结论西那卡塞联合小剂量骨化三醇治疗重度继发性甲状旁腺功能亢进的效果较好,可显著改善患者的骨代谢功能,减少不良反应的发生,值得临床推广。

Objective To analyze the effect of cinacalcet combined with low-dose calcitriol in the treatment of severe secondary hyperparathyroidism and the influence on bone metabolism.Methods 80 patients with severe secondary hyperparathyroidism admitted to our hospital were selected and randomly divided into observation group and control group,with 40 cases in each group.The control group was only treated with cinacalcet,while the observation group was treated with cinacalcet combined with low-dose calcitriol.The treatment effect was compared between the two groups.Results The total effective rate of treatment in the observation group was 92.50%,higher than 75.00%in the control group(P<0.05).After treatment,the ALP,OC andβ-cross levels in the two groups decreased,and the ALP,OC andβ-cross levels of the the observation group were lower than those of the control group(P<0.05).The incidence of adverse reactions in the observation group was 5.00%,lower than 20.00%in the control group(P<0.05).Conclusions Cinacalcet combined with low-dose calcitriol in the treatment of severe secondary hyperparathyroidism has better effect,can significantly improve the bone metabolic function of patients,and reduce the adverse reactions,which is worthy of clinical promotion.