奥美拉唑联合奥曲肽急诊治疗对急性上消化道出血患者临床疗效与出血率的影响

Influence of Omeprazole Combined with Octreotide Emergency Treatment on Clinical Efficacy and Bleeding Rate in Patients with Acute Upper Gastrointestinal Bleeding

目的分析奥美拉唑联合奥曲肽急诊治疗对急性上消化道出血患者临床疗效与出血率的影响。方法选择2018年2月至2019年12月我院收治的急性上消化道出血患者60例,随机为对照组和观察组各30例。对照组采用奥美拉唑单一治疗(静脉滴注,2次/d,单次间隔12 h),观察组采用奥美拉唑联合奥曲肽治疗(25μg/h静脉泵注,1次/d,连续治疗7 d)。比较两组患者的临床疗效及二次出血率。结果观察组的治疗总有效率为96.67%,高于对照组的76.67%(P <0.05)。观察组的二次出血率为3.33%,低于对照组的26.67%(P <0.05)。结论奥美拉唑联合奥曲肽治疗急性上消化道出血效果显著,能有效降低二次出血率,值得临床推广应用。

Objective To analyze the influence of omeprazole combined with octreotide emergency treatment on clinical efficacy and bleeding rate of patients with acute upper gastrointestinal bleeding. Methods 60 patients with acute upper gastrointestinal bleeding admitted to our hospital from February 2018 to December 2019 were selected and randomly divided into control group and observation group, with 30 cases in each group. The control group was only treated with omeprazole(intravenous drip, twice a day with an interval of 12 hours). The observation group was treated with omeprazole combined with octreotide(25 μg/h intravenous pump injection, once a day for 7 consecutive days). The clinical efficacy and secondary bleeding rate were compared between the two groups. Results The total effective rate of treatment in the observation group was 96.67%, higher than 76.67% in the control group(P <0.05). The secondary bleeding rate of the observation group was 3.33%, lower than 26.67% of the control group(P <0.05). Conclusions Omeprazole combined with octreotide has significant effect in the treatment of acute upper gastrointestinal bleeding, and can effectively reduce the secondary bleeding rate, which is worthy of clinical promotion and application.