吉非替尼联合化疗治疗肺癌患者的效果及对N SE、LTBP2水平的影响

Effect of Gefitinib Combined with Chemotherapy in the Treatment of Patients with Lung Cancer and the Influence on NSE and LTBP2 Levels

目的探讨吉非替尼联合化疗治疗肺癌患者的效果及对NSE、LTBP2水平的影响。方法选择2016年6月至2018年1月我院收治的肺癌患者102例,随机平均分为两组。对照组采用常规化疗方案,观察组在对照组基础上采用吉非替尼治疗。比较两组患者的近期疗效及NSE、LTBP2、SCCAg、bFGF水平。结果治疗3个疗程后,观察组的有效率为54.90%,高于对照组的35.29%(P<0.05);观察组的NSE、SCCAg、LTBP2、bFGF水平低于对照组(P<0.05)。结论吉非替尼联合化疗治疗肺癌患者能够提高近期疗效,降低肿瘤细胞因子水平,值得推广应用。

Objective To explore the effect of gefitinib combined with chemotherapy in the treatment of patients with lung cancer and the influence on NSE and LTBP2 levels.Methods 102 patients with lung cancer admitted to our hospital from June 2016 to January 2018 were selected and randomly divided into two groups equally.The control group was given routine chemotherapy,and the observation group was treated with gefitinib on the basis of the control group.The short-term efficacy and the levels of NSE,LTBP2,SCCAg and bFGF were compared between the two groups.Results After 3 courses of treatment,the effective rate of the observation group was 54.90%,higher than 35.29%of the control group(P<0.05);The levels of NSE,SCCAg,LTBP2 and bFGF in the observation group were lower than those in the control group(P<0.05).Conclusions Gefitinib combined with chemotherapy in the treatment of patients with lung cancer can improve the short-term efficacy,and reduce the levels of tumor cytokines,which is worthy of promotion and application.