沙丁胺醇联合干扰素α1b雾化吸入治疗毛细支气管炎患儿的效果观察

Observation on the Effect of Salbutamol Combined with Interferon α1b Aerosol Inhalation in the Treatment of Children with Bronchiolitis

目的观察沙丁胺醇联合干扰素α1b雾化吸入治疗毛细支气管炎患儿的临床效果。方法选取2018年6月至2020年6月我院收治的120例毛细支气管炎患儿,随机分为对照组和观察组各60例。在常规治疗基础上,对照组采用沙丁胺醇雾化吸入治疗,观察组采用沙丁胺醇联合干扰素α1b雾化吸入治疗,两组均连续治疗7 d。比较两组的相关症状消失时间、治疗效果及不良反应。结果观察组的喘憋、咳嗽、肺啰音消失时间均明显短于对照组(P<0.05)。观察组的治疗总有效率为93.33%,明显高于对照组的80.00%(P<0.05)。治疗期间,两组患儿的不良反应发生率(6.67%vs.3.33%)比较,差异无统计学意义(P>0.05)。结论沙丁胺醇联合干扰素α1b雾化吸入治疗毛细支气管炎患儿效果显著,可有效缩短其喘憋、咳嗽、肺啰音消失时间,且安全性较高,值得临床推广应用。

Objective To observe the clinical effect of salbutamol combined with interferon α1b aerosol inhalation in the treatment of children with bronchiolitis.Methods 120 children with bronchiolitis admitted to our hospital from June 2018 to June 2020 were selected and randomly divided into control group(n=60)and observation group(n=60).On the basis of routine treatment,the control group was treated with salbutamol atomization inhalation,and the observation group was treated with salbutamol combined with interferon α1b aerosol inhalation.Both groups were treated for 7 days continuously.The disappearance time of related symptoms,treatment effect and adverse reactions were compared between the two groups.Results The disappearance time of asthma,cough and lung rale in the observation group was significantly shorter than that in the control group(P<0.05).The total effective rate of treatment in the observation group was 93.33%,significantly higher than 80.00%in the control group(P<0.05).During treatment,no statistical difference was found in the incidence of adverse reactions(6.67%vs.3.33%)between the two groups(P>0.05).Conclusions Salbutamol combined with interferon α1b aerosol inhalation in the treatment of children with bronchiolitis has significant effect,and can effectively shorten the disappearance time of asthma,cough and lung rale,with higher safety,which is worthy of clinical promotion and application.