血清淀粉样蛋白A在银屑病发病机制中作用的研究进展

Research advances in role of serum amyloid A in pathogenesis of psoriasis

血清淀粉样蛋白A(serum amyloid A,SAA)是一种急性时相反应蛋白。正常情况下可在多个器官与组织内表达,在人体受到打击或应激时其浓度可迅速升高。SAA可作为促炎性因子与特定受体结合并激活下游信号通路诱导T细胞为主的免疫反应。在许多自身免疫性疾病(如类风湿关节炎)以及慢性代谢性疾病(如2型糖尿病)中均发现该蛋白的参与,并诱导Th17细胞的分化。本文就SAA在银屑病发病机制中的作用做简要综述。

Serum amyloid protein A(SAA)is an acute phase reaction protein.Normally,it can be expressed in various organs and tissues,and its concentration can increase rapidly when the human body is under attack or stressed.Recently,several studies have revealed that SAA can work as a pro-inflammatory factor to bind to specific receptors and activate downstream signal pathways to induce T-cell-dominated immune response.Multiple studies have suggested that the involvement of the protein in many autoimmune diseases such as rheumatoid arthritis and type 2 diabetes.And,SAA is found to be involved in the pathogenesis of psoriasis and it can induce the differentiation of Th17.This article briefly reviews the role of SAA in the pathogenesis of psoriasis.