EMT在瘢痕疙瘩中的作用研究进展

Recent Advance in the Role of EMT in Keloid

上皮间质转化(epithelial-to-mesenchymal transition,EMT)是上皮细胞极性丧失且发展为具有迁移和侵袭特性的间充质细胞的动态过程。EMT已被证实与伤口愈合、器官纤维化及癌症发展有关。瘢痕疙瘩的研究都专注于瘢痕疙瘩成纤维细胞,近几年来广大学者们开始注重瘢痕疙瘩角化上皮细胞侵袭周围正常皮肤的现象。有证据表明EMT与瘢痕疙瘩的侵袭性、持续生长的类肿瘤特性有关。本文重点探讨EMT与瘢痕疙瘩的关系,为瘢痕疙瘩的治疗提供了一个新方向。

Epithelial-to-mesenchymal transition(EMT)is a process associated with the loss of polarity of epithelial cells and their development into mesenchymal cells with invasive and migratory properties.EMT has been shown to be involved in wound healing,organ fibrosis and development of cancer.The research of keloids is focused on keloid fibroblasts.In recent years,scholars have begun to pay attention to the phenomenon of keloid keratinocytes invading the surrounding normal skin.There is evidence that EMT is associated with the aggressive,continuously growing tumor-like characteristics of keloids.The article focuses on the relationship between EMT and keloid,and provides a new direction for the treatment of keloid.