PDX模型在胃癌研究方面的应用与挑战

Application and challenges of a patient-derived xenograft model in the study of gastric cancer

在我国,胃癌发病率随着人口老龄化的越来越严重将成上升趋势,而它又是死亡率较高的恶性肿瘤。现如今,缺乏有效的抗肿瘤药物是关键因素,故临床前研究至关重要,动物模型与其密切相关。现代研究强调肿瘤的精准治疗,于是人源性异种移植模型(patient-derived xenograft,PDX)应运而生,它与病人原始肿瘤的生物特征有很高的一致性,弥补了传统细胞系模型的不足,为肿瘤研究提供了新的平台选择。本文综述了胃癌PDX模型的建立方法,归纳了近几年来的研究应用,提出了建立胃癌PDX模型的挑战。

In China,the incidence of gastric cancer has increased with the aging population,and this is a malignant cancer with high mortality.Currently,the lack of effective anti-tumor drugs is a key concern;therefore,preclinical research is crucial,and animal models are important.Modern research emphasizes precise tumor treatment,and patient-derived xenografts(PDX)have emerged from related research.PDX are highly consistent with the biological characteristics of the original tumor,which addresses the deficiencies of the traditional cell line model and provides a new platform for tumor research.In this paper,we review the established method of PDX modelling for gastric cancer.We also summarize the related research and its application in recent years.