奥曲肽联合奥美拉唑治疗急性上消化道出血效果观察

Observation on the Clinical Effect of Octreotide and Omeprazole in the Treatment of Acute Upper Gastrointestinal Bleeding

目的观察奥曲肽与奥美拉唑联合用药方案治疗急性上消化道出血效果分析。方法将在中山大学附属第一医院2017年7—12月收治急性上消化道出血为诊断并接受常规治疗的68例患者作为研究对象,以随机数字表法分成两组,即每组34例患者,选取其中34例患者使用奥美拉唑治为对照组,选取另34例使用奥曲肽联合奥美拉唑设置为试验组。比较两组患者临床治疗指标(出血量、输血量、止血时间、住院时间),治疗前、后胃相关指标(胃液pH水平、胃泌素水平),临床疗效。结果试验组出血量、输血量少于对照组,且止血时间与住院时间短于对照组,差异具有统计学意义(P<0.05)。治疗前,两组患者胃液pH值、胃泌素的胃相关指标,差异无统计学意义(P>0.05)。治疗后两组患者胃液pH值升高,试验组高于对照组,胃泌素水平降低,试验组低于对照组,差异具有统计学意义(P<0.05)。治疗后试验组总有效率(94.12%)高于对照组(76.47%),差异具有统计学意义(P<0.05)。结论在急性上消化道出血患者的相关治疗中,实施以奥曲肽与奥美拉唑联合用药方案治疗,可减少患者的出血量与输血量,改善治疗后的胃液pH值与胃泌素水平,提升临床治疗疗效,缩短住院时间。

Objective To observe and analyze the clinical effect of octreotide and omeprazole in the treatment of acute upper gastrointestinal bleeding.Methods The 68 patients who were diagnosed with acute upper gastrointestinal bleeding in our hospital from July 2017 to December 2017 and received conventional treatment were divided into two groups by random number table,34 cases in each group.Among the patients,34 patients were selected as the control group treated with omeprazole,and 34 patients were selected as the experimental group treated with octreotide combined with omeprazole.The clinical treatment indexes(bleeding volume,blood transfusion volume,hemostasis time,hospitalization time),gastric-related indexes(gastric juice pH level,gastrin level)before and after treatment,and clinical treatment efficacy were compared between the two groups.Results The amount of bleeding and blood transfusion in the experimental group was significantly less than that in the control group,and the time to hemostasis and hospital stay were shorter than those in the control group.The difference was statistically significant(P<0.05).Before treatment,the pH value of gastric juice and gastrin related indexes between the two groups were not statistically different(P>0.05).The gastric juice pH value of the two groups of patients increased after treatment,the experimental group was higher than the control group,and the gastrin level decreased,and the experimental group was lower than the control group.The difference was statistically significant(P<0.05).After treatment,the total effective rate of the experimental group(94.12%)was higher than that of the control group(76.47%),and the difference was statistically significant(P<0.05).Conclusion In the related treatment of patients with acute upper gastrointestinal bleeding,the combined treatment of octreotide and omeprazole can significantly reduce the amount of bleeding and blood transfusion in patients,and improve the pH and gastrin of gastric juice after treatment Level,improve clinical treatment efficacy,shorten hospitalization time,and achieve ideal results.