FEZF1-AS1在子宫内膜癌中的表达及其与患者临床特征的相关性

Expression of FEZF1-AS1 in Endometrial Carcinoma and Its Correlation with Clinical Characteristics of Patients

目的探讨FEZ家族锌指1反义RNA 1(FEZF1-AS1)在子宫内膜癌(endometrial cancer,EC)中的表达及其与临床病理的相关性。方法选取2010年1月~2018年1月安康市人民医院收治的172例EC患者为研究对象,通过实时荧光定量PCR(quantitative real-time PCR,qPCR)分别检测患者的EC组织和癌旁正常组织中FEZF1-AS1的相对表达量,并且分析FEZF1-AS1表达水平与EC患者临床特征之间的关系。结果FEZF1-AS1在EC组织中的相对表达量显著高于癌旁正常组织(P=0.007),其表达水平与EC患者家族肿瘤史(χ^2=6.891,P=0.016)、病理分级(χ^2=7.142,P=0.028)、肿瘤分期(χ^2=10.426,P=0.002)、T分期(χ^2=8.248,P=0.007)和M分期(χ^2=10.405,P=0.002)显著相关。结论FEZF1-AS1在EC中高表达,且其与患者的家族肿瘤史、病理分级和肿瘤分期等相关。

Objective To investigate the expression of FEZF1-AS1 in endometrial carcinoma(EC)and its correlation with clinicopathology.Methods A total of 172 EC patients admitted to Ankang People’s Hospital from January 2010 to January 2018 were selected as the research objects.Quantitative real-time PCR(qPCR)was used to detect the relative expression level of FEZF1-AS1 in the EC tissues and adjacent normal tissues of the patients,and the relationship between the expression level of FEZF1-AS1 and the clinical characteristics of EC patients was analyzed.Results The relative expression level of FeZF1-AS1 in EC tissues was significantly higher than that in adjacent normal tissues(P=0.007),and its expression level was significantly correlated with the family tumor history(χ^2=6.891,P=0.016),pathological grade(χ^2=7.142,P=0.028),tumor stage(χ^2=10.426,P=0.002),T stage(χ^2=8.248,P=0.007),and M stage(χ^2=10.405,P=0.002)of EC patients.Conclusion FEZF1-AS1 was highly expressed in EC,and it was related to the family tumor history,pathological grade and tumor stage of the patient.