2005年~2015年三亚地区出生低体重儿罹患慢性肾脏病危险因素的横断面研究

A Cross-sectional Study on the Risk Factors of Chronic Kidney Disease in Low Birth Weight Infants in Sanya from 2005 to 2015

目的调查三亚地区2005年~2015年出生低体重儿罹患慢性肾脏疾病(CKD)的检出率,分析其危险因素。方法收集2005~2015年海南省三亚地区3个重点医院的出生低体重儿,对所有可追溯的儿童进行为期24个月随访,观察CKD的筛出率,采用Logistic回归分析出生低体重儿发生CKD的危险因素。结果最终纳入1219例低出生体重儿,共确诊CKD患儿33例,检出率为2.71%,其中CKDⅠ期20例,CKDⅡ期13例;单因素分析显示,不同孕周、出生体重、血肌酐、Ccr、舒张压、血尿素氮、血清白蛋白、尿白蛋白、空腹血糖、运动行为指数的出生低体重儿CKD的检出率比较,差异有统计学意义(P<0.05);二元Logistic回归分析显示,孕周、Ccr、血清白蛋白和运动行为指数是早产儿及出生低体重儿罹患CKD的保护因素,血肌酐、舒张压、尿白蛋白、空腹血糖是早产儿及出生低体重儿罹患CKD的危险因素。结论血肌酐、舒张压、尿白蛋白、空腹血糖是低出生体重儿发生CKD的危险因素,而高运动指数、高血清白蛋白、高孕周有利于降低低出生体重儿CKD的发生。

Objective To investigate the detection rate of chronic kidney disease(CKD)in low birth weight infants in Sanya from 2005 to 2015,and analyze its risk factors.Methods A collection of low birth weight infants from three key hospitals in Sanya,Hainan Province from 2005 to 2015 was conducted.All traceable children were followed up for 24 months to observe the screening rate of CKD.Logistic regression was used to analyze the risk factors of CKD in low birth weight infants.Results Finally,1219 low birth weight infants were included.A total of 33 children with CKD were diagnosed with a detection rate of 2.71%,including 20 cases of CKD stage I and 13 cases of CKD stage II;Univariate analysis showed that the detection rate of CKD in low birth weight infants with different gestational weeks,birth weight,blood creatinine,Ccr,diastolic blood pressure,blood urea nitrogen,serum albumin,urine albumin,fasting blood glucose,and exercise behavior index were compared,the difference was statistically significant(P<0.05);Binary Logistic regression analysis showed that gestational age,Ccr,serum albumin and exercise behavior index are the protective factors for premature infants and low birth weight infants from CKD.Serum creatinine,diastolic blood pressure,urine albumin,and fasting blood glucose were preterm infants and births.Risk factors for CKD in low birth weight infants.Conclusion Serum creatinine,diastolic blood pressure,urine albumin,and fasting blood glucose are risk factors for CKD in low birth weight infants.High exercise index,high serum albumin,and high gestational age are beneficial to reduce the occurrence of CKD in low birth weight infants.