摘要
腺苷酸活化蛋白激酶(AMP-activated protein kinase,AMPK)是一种AMP依赖性的蛋白激酶,负责调节细胞能量的合成与分解,是细胞生长、繁殖和自噬的关键调节剂。AMPK及其信号通路在病毒、细菌和寄生虫等感染中发挥了重要作用,有望成为一种药物新靶点。本文将对近年来AMPK信号通路在感染性疾病中的研究展开综述。
AMP-activated protein kinase(AMPK),an AMP-dependent protein kinase responsible for regulating the synthesis and catabolism of cellular energy,is a key regulator for cell growth,reproduction and autophagy.AMPK and its signaling pathway play an important role in viral,bacterial and parasitic infections and are expected to be a new drug target.In this paper,we reviewed the recent research on AMPK signaling pathway in infectious diseases.
作者
颜明智
赵军
刘辉
毕晓娟
吕国栋
YAN Ming-zhi;ZHAO Jun;LIU Hui;BI Xiao-juan;Lü Guo-dong(State Key Laboratory of Pathogenesis,Prevention and Treatment of Central Asian High Incidence Diseases,Clinical Medical Research Institute,The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,Xinjiang Uygur Autonomous Region,China;College of Pharmacy,Xinjiang Medical University;Department of Clinical Pharmacy,The First Affiliated Hospital of Xinjiang Medical University)
出处
《热带病与寄生虫学》
2021年第1期47-51,共5页
Journal of Tropical Diseases and Parasitology
基金
国家自然科学基金项目(82060373,81760369)
省部共建中亚高发病成因与防治国家重点实验室开放课题(SKL-HIDCA-2017-Y1)
中国博士后科学基金面上项目(2019M653802)。
