瑞芬太尼与舒芬太尼对ERAS策略下新生儿胃肠穿孔修补术的影响比较

Comparison of effects of remifentanil and sufentanil on repair of neonatal gastrointestinal perforation under ERAS strategy

目的比较瑞芬太尼与舒芬太尼对快速康复外科(ERAS)策略下新生儿胃肠穿孔修补术的影响。方法选取2019年3月至2019年9月我院新生儿科行胃肠穿孔修补术的50例患儿,随机将其分为瑞芬太尼组(R组)及舒芬太尼组(S组),每组25例。比较两组患儿手术不同时间的平均动脉压、心率;比较两组患儿术中多巴胺用量、手术时间、拔管时间、转科时间及ICU期间治疗费用。结果T2、T3时,S组的平均动脉压和心率均低于R组(P<0.05);S组的多巴胺用量高于R组(P<0.05);S组的拔管时间长于R组,ICU期间治疗费用高于R组(P<0.05)。结论瑞芬太尼用于新生儿胃肠穿孔修补术中,对心血管抑制轻,能够更好地维持血流动力学稳定,且术后拔管时间短,治疗费用低,值得临床推广。

Objective To compare the effects of remifentanil and sufentanil on repair of neonatal gastrointestinal perforation under enhanced recovery after surgery(ERAS)strategy.Methods A total of 50 children undergoing gastrointestinal perforation repair in neonatology department of our hospital from March 2019 to September 2019 were selected and randomly divided into remifentanil group(group R)and sufentanil group(group S),with 25 cases in each group.The mean arterial pressure and heart rate at different operation time were compared between the two groups;the intraoperative dopamine dosage,operation time,extubation time,transfer time and treatment cost in ICU were compared between the two groups.Results At T2 and T3,the mean arterial pressure and heart rate in the group S were lower than those in the group R(P<0.05);the dosage of dopamine in the group S was higher than that in the group R(P<0.05);the extubation time in the group S was longer than that in the group R,and treatment cost in ICU was higher than that in the group R(P<0.05).Conclusion Remifentanil is used in the repair of neonatal gastrointestinal perforation,with less cardiovascular inhibition,better maintenance of hemodynamic stability,short postoperative extubation time and low treatment cost,which is worthy of clinical promotion.