帕金森病病人焦虑现状及影响因素研究

Clinical Study on Anxiety Status and Influencing Factors of Parkinson′s Disease

目的分析帕金森病(PD)病人焦虑现状,并探讨其影响因素。方法选择在四川大学华西医院神经内科门诊就诊的197例PD病人,收集情绪资料、一般资料及疾病特征资料。应用单因素及多因素回归分析影响PD病人焦虑的因素。结果43例(21.8%)PD病人发生焦虑。二元Logistic回归分析显示,汉密尔顿焦虑量表(HAMD)评分[OR=29.923,95%CI(6.709,133.462),P<0.001];患病前规律体育锻炼[OR=4.785,95%CI(1.624,14.100),P=0.005]、运动波动[OR=3.685,95%CI(1.206,11.263),P=0.022]、PD综合评定量表(UPDRS)Ⅲ评分[OR=0.953,95%CI(0.910,0.998),P=0.041]、改良Barthel指数(MBI)评分[OR=0.955,95%CI(0.922,0.989),P=0.010]、简易精神状态量表(MMSE)评分[OR=0.839,95%CI(0.736,0.957),P=0.009]为PD病人焦虑的独立影响因素。结论焦虑在PD病人中较常见,若伴发抑郁、运动波动、在患病前进行规律的体育锻炼、认知功能障碍、生活自理能力低下及病情严重均会增加焦虑的风险。

Objective To investigate the anxiety status and influencing factors in patients of Parkinson′s Disease(PD).Methods One hundred and ninety-seven PD patients were collected.The emotional,general and clinical data were collected.Assessments of emotional,physical,cognitive status were collected during interview.Multivariate Logistic regressions were used to analyze the risk factors of anxiety in patients with PD.Results Forty three(21.8%)patients had anxious.Logistic regression showed that HAMD[OR=29.923,95%CI(6.709,133.462),P=0.000],regular exercise before illness[OR=4.785,95%CI(1.624,14.100),P=0.005],fluctuation[OR=3.685,95%CI(1.206,11.263),P=0.022],UPDRSⅢ[OR=0.953,95%CI(0.910,0.998),P=0.041];MBI[OR=0.955,95%CI(0.922,0.989),P=0.010],MMSE[OR=0.839,95%CI(0.736,0.957),P=0.009]were independent risk factors of anxious in patients with PD.Conclusion Anxious was a common problem in PD patients.Accompanied by depression,movement fluctuations,regular physical exercise before illness,cognitive dysfunction,low self-care ability,and serious illness could increase the risk of anxiety.