贝那普利氢氯噻嗪片基层临床应用全科专家共识

Chinese General Practice Experts Consensus on the Use of Benazepril Hydrochloride and Hydrochlorothiazide Tablets in Primary Care

固定配比的单片复方制剂已被证明可提高高血压患者治疗的依从性和血压控制率、改善患者预后。贝那普利氢氯噻嗪片用于治疗高血压已在国内外应用多年,积累了大量临床应用证据和经验,在基层高血压的治疗和管理中起到了积极作用,但目前基层全科医生在临床应用时尤其是对于含氢氯噻嗪成分药物的应用仍存在一些疑虑,导致应用不足现象比较严重。为进一步加强和指导基层全科医生认识并合理应用贝那普利氢氯噻嗪片,促进高血压在基层的规范化管理,中国医师协会全科医师分会特组织相关领域专家组成专家共识组,基于最新的高质量循证证据和国内外相关指南制定本共识,主要内容包括贝那普利氢氯噻嗪片的特点和临床获益、在高血压及高血压合并其他疾病中的临床应用和基层应用要点,以期指导基层全科医生合理规范化应用贝那普利氢氯噻嗪片。

There is sufficient evidence that the fixed-dose single-pill combination can improve the therapy adherence and the rate of meeting the target blood pressure level in patients with hypertension,improving their prognosis.Benazepril hydrochloride and hydrochlorothiazide tablets(BHHT)have been used for hypertension for many years,which has proved to play a positive role in the treatment and management of hypertension in primary care by a great deal of clinical evidence.However,due to doubts about clinical use of BHHT,especially medicines containing hydrochlorothiazide,these medicines are underused seriously in primacy care by general practitioners(GPs).To increase GPs’understanding of BHHT and guide them to rationally use BHHT to promote standardized management of hypertension in primary care,China General Practitioner Association,Chinese Medical Doctor Association invited a panel of general practice experts to compile this consensus based on the latest high-quality evidence and relevant guidelines,which mainly includes characteristics and clinical benefits of BHHT,clinical application of BHHT in hypertension and hypertension with other diseases,and the main points for clinical application of BHHT in primary care,to guide the rational and standardized application of BHHT in primary care.