多索茶碱与氨茶碱治疗支气管哮喘的效果观察及不良反应发生率评价

Effect Observation and Adverse Reaction Rate Evaluation of Doxofylline and Aminophylline in the Treatment of Bronchial Asthma

目的对比多索茶碱与氨茶碱在支气管哮喘患者中的应用效果以及不良反应。方法选取山东省东营市第二人民医院呼吸内科2018年6月至2020年1月收治148例支气管哮喘患者为研究对象,根据随机数字表法分为两组,每组74例。A组患者应用多索茶碱,B组患者应用氨茶碱。治疗7 d后对比两组的总有效率、不良反应发生率、肺功能等。结果A组患者的治疗总有效率94.59%,高于B组的治疗总有效率83.78%,(P<0.05);治疗7 d后,A组患者的呼气容积、用力肺活量、呼气流速峰值水平均高于B组(P<0.05);A组治疗后的炎症细胞因子白细胞介素-18、白细胞介素-33、肿瘤坏死因子-α水平均低于B组(P<0.05);A组的不良反应发生率6.76%,显著低于B组18.92%,(P<0.05)。结论相较于氨茶碱,多索茶碱在支气管哮喘患者中应用疗效肯定,有助于促进患者肺功能的好转和炎症反应缓解,且安全性更高。

Objective To compare the application effect of doxofylline and aminophylline in patients with bronchial asthma and the influence on the incidence of adverse reactions.Methods A total of 148 patients with bronchial asthma admitted to the Department of respiratory medicine of Second People's Hospital of Dongying City,Shandong Province,from June 2018 to January 2020 were selected as the research objects and divided into two groups by random number table,with 74 cases each group.The patients in group A were treated with doxofylline,and patients in group B were treated with aminophylline.After 7 day treatment,the total effective rate,incidence of adverse reactions and lung function of the two groups were compared.Results The total effective rate of group A 94.59%was higher than that of group B 83.78%(P<0.05);After 7 day of treatment,patients in group A had higher peak expiratory volume,forced vital capacity,and expiratory flow rate than those in group B(P<0.05);the levels of inflammatory cytokines IL-18,IL-33 and TNF-αin group A were lower than those in group B(P<0.05);the incidence of adverse reactions in group A was 6.76%,which was lower than that in group B 18.92%(P<0.05).Conclusion Compared with aminophylline,doxofylline in patients with bronchial asthma has definite curative effect,which is helpful to promote the improvement of lung function and the remission of inflammatory reaction,and has higher safety.