抗生素降阶梯疗法在糖尿病重症肺炎患者中的临床应用效果

Clinical Effect of Antibiotic Step-Down Therapy in Patients with Severe Diabetes Pneumonia

目的探究抗生素降阶梯疗法在糖尿病重症肺炎患者中的临床应用效果。方法选取房山区第一医院2019年8月至2020年8月收治的糖尿病重症肺炎患者80例,按随机数字表法分为对照组(40例)与研究组(40例),对照组采用常规抗生素治疗,研究组采用抗生素降阶梯疗法。对比两组患者治疗总有效率、平均住院时间、抗生素使用时间、真菌定植发生率、病死率、肺部CT病灶吸收率、感染控制时间。结果研究组治疗总有效率95.00%,高于对照组总有效率75.00%,组间比较差异有统计学意义(χ^2=6.275,P<0.05)。研究组平均住院时间、抗生素使用时间、感染控制时间短于对照组(P<0.05);研究组真菌定植发生率2.50%、病死率2.50%均低于对照组的25.00%和30.00%(P<0.05);研究组肺部CT病灶吸收率(22.54±4.54)%高于对照组(14.64±3.42)%(P<0.05)。结论抗生素降阶梯疗法在糖尿病重症肺炎患者中的临床应用,能够缩短平均住院时间、抗生素使用时间、感染控制时间,降低病死率。

Objective To explore the clinical effect of antibiotic step-down therapy in patients with severe diabetes pneumonia.Methods A total of 80 patients with severe diabetic pneumonia admitted to Fangshan District First Hospital from August 2019 to August 2020 were randomly divided into control group(n=40,conventional antibiotic treatment)and study group(n=40,antibiotic step-down therapy).The total effective rate,average hospitalization time,antibiotic use time,fungal colonization rate,mortality rate,lung CT lesion absorption rate and infection control time were compared between the two groups.Results The total effective rate of the study group was 95.00%,which was higher than that of the control group 75.00%.There was a significant difference between the groups(χ^2=6.275,P<0.05).The average hospitalization time,antibiotic use time and infection control time of the study group were shorter than those of the control group(P<0.05);the incidence of fungal colonization in the study group was 2.50%,and the mortality rate was 2.50%,which were lower than 25.00%and 30.00%of the control group(P<0.05);the lung CT lesion absorption rate in the study group(22.54±4.54)%was higher than that in the control group(14.64±3.42)%(P<0.05).Conclusion The clinical application of antibiotic step-down therapy in patients with severe diabetes pneumonia,can shorten the average length of hospital stay,antibiotic use time,infection control time,and reduce the fatality rate.