脊髓损伤干细胞治疗的研究现状与未来

Research status and future of stem cell therapy for spinal cord injury

脊髓损伤是一种严重的中枢神经系统损伤,致残率高、并发症多、预后差。近二十年,尽管脊髓损伤的外科治疗取得一定进展,但仍无法从根本上改善脊髓损伤患者的临床预后。干细胞治疗被视为再生医学中最具应用前景的治疗手段之一。近年来,干细胞移植、刺激自体潜在的干细胞分化等干细胞治疗脊髓损伤已取得一定成果,但其临床转化仍存在诸多瓶颈。笔者回顾近年来脊髓损伤干细胞治疗的研究现状并对其未来进行展望,为脊髓损伤干细胞治疗相关研究提供参考。

Spinal cord injury is a serious central nervous system injury,with a high disability rate,many complications and poor prognosis.Although surgical treatment of spinal cord injury has made some progress in the past two decades,it still cannot fundamentally improve the clinical prognosis of patients with spinal cord injury.Stem cell therapy is regarded as one of the most promising treatments in regenerative medicine.Although some achievements have been made in stem cell therapy for spinal cord injury in recent years,such as stem cell transplantation and stimulation of differentiation of autologous potential stem cells,there are still many bottlenecks in its clinical transformation.The authors review the research status of stem cell therapy for spinal cord injury in recent years and prospect its future,hoping to provide references for the further studies.