内皮细胞相关动静脉分化调控的研究进展

Research progress of regulating endothelial cell related arteriovenous differentiation

动静脉分化(arteriovenous differentiation)是一类由多基因、多因素参与且程序性调控的基础生命活动,其中,动静脉内皮细胞相关的分化调控是最为关键的前提之一,Hedgehog、VEGF、Notch、COUP-TFⅡ等各类血管发育相关信号通路共同参与血管内皮细胞的分化调控,但在该过程中的表达及作用不尽相同。此外,血流动力学因素也是动静脉内皮分化不可或缺的因素之一。本文从动静脉内皮细胞的分子标志物、相关信号通路、血流动力学等方面,总结近年来血管内皮细胞相关动静脉分化调控的研究进展。

Arteriovenous differentiation is a regulated programmatically biological process that involves multi-genetics and multi-factors. The regulation of differentiation of arteriovenous endothelial cells(EC) is one of the most critical prerequisites for this process. Hedgehog, VEGF, Notch, COUP-TF Ⅱ and other vascular development-related signaling pathways participate in regulating the differentiation of endothelial cells. However, the expression levels and functions of above molecules in this process are variant. In addition, hemodynamic is also an indispensable factor for arteriovenous endothelial differentiation. This article reviewed progression of arteriovenous differentiation of vascular endothelial cell in recent years, from aspects of molecular markers, related signaling pathways, and hemodynamics of arteriovenous endothelial cells.