育龄期女性缺铁性贫血患者血清铁调素和erythroferrone水平的变化

Hepcidin and Erythroferrone Levels in Child-Bearing Women with Iron Deficiency Anemia

目的:检测育龄期女性缺铁性贫血(Iron deficiency anemia,IDA)患者血清铁调素和erythroferrone(ERFE)含量,并探讨其与铁代谢各参数的相关性。方法:选取住院育龄期女性缺铁性贫血患者35例,年龄相匹配的健康女性对照人群30例。采用全自动电化学发光仪检测血清铁蛋白水平,全自动生化仪测定血清铁含量,采用酶联免疫吸附法测定血清铁调素和erythroferrone水平。使用SPSS22.0软件分析两组间各变量差异;变量间的相关性采用Spearman相关性分析。结果:与对照组相比,育龄期女性缺铁性贫血患者血红蛋白、血清铁、铁蛋白和转铁蛋白饱和度均显著降低(P<0.001)。IDA组血清铁调素水平明显低于对照组(P<0.001);血清erythroferrone水平在IDA组中轻微升高(P>0.05)。血清铁调素与血红蛋白、血清铁、铁蛋白和转铁蛋白饱和度均呈正相关(r=0.448,r=0.496,r=0.754,r=0.491);血清erythroferrone水平与血红蛋白、血清铁、铁蛋白、转铁蛋白饱和度及铁调素均不存在相关性(P>0.05)。结论:育龄期女性缺铁性贫血患者血清铁调素水平显著下降,而血清erythroferrone水平无明显变化,这提示erythroferrone在育龄期女性轻中度缺铁性贫血中可能不参与铁代谢调控过程。

Objective:To detect serum hepcidin and erythroferrone levels in child-bearing women with iron deficiency anemia(IDA),and to investigate the association between them and iron status parameters.Methods:The study consisted of 65 child-bearing women(35 with iron deficiency anemia and 30 age-matched healthy women).The levels of serum iron were detected by using automated chemistry analyzer,the contents of serum ferritin were detected by electrochemiluminescence immunoassay,and the levels of serum erythroferrone and hepcidin were detected by specific enzyme-linked immunosorbent assay(ELISA) kit.The quantitative variables between two groups were compared and analyzed by SPSS22.0 software.Spearman correlation was used to detect correlation between the parameters.Results:The levels of Hb,serum iron,ferritin and transferrin saturation were significantly decreased in IDA patients as compared with in control group(P<0.001).Serum hepcidin levels in IDA patients were significant lower than those in control group(P<0.001).Serum erythroferrone levels slightly increased in IDA group(P>0.05).In IDA patients,serum hepcidin concentrations were positively correlated with hemoglobin concentration,serum iron,serum ferritin and transferrin saturation(r=0.448,r=0.496,r=0.754,r=0.491).But,serum erythroferrone concentrations showed no correlation with hemoglobin concentration,serum iron,serum ferritin,transferrin saturation and hepcidin(P>0.05).Conclusion:Serum hepcidin levels were significantly decreased in child-bearing women with IDA,but the serum erythroferrone levels were not obviously different between two groups,suggesting that serum erythroferrone may be not involved in the regulation of iron metabolism in child-bearing women with mild and moderate IDA.