皮下脂膜炎样T细胞淋巴瘤研究进展

Research Progression of Subcutaneous Panniculitis-like T-Cell Lymphoma——Review

皮下脂膜炎样T细胞淋巴瘤(SPTCL)是一类非常罕见的来源于细胞毒性T细胞的皮肤恶性淋巴瘤,主要累及皮下脂肪组织,而不累及表皮与真皮,好发于中青年,临床常表现为皮下斑块、结节或皮肤溃疡,可有肿痛,好发于四肢和躯干。WHO-EORTC将SPTCL限定于α/β表型,而将γ/δ表型归类于皮肤γ/δ^+T细胞淋巴瘤。目前SPTCL病因尚不十分清楚,无标准的治疗方案,患者整体预后相对良好。本文对SPTCL的近年研究进展做一综述。

Subcutaneous panniculitis-like T-cell lymphoma(SPTCL)is a very rare cutaneous malignant lymphoma derived from cytotoxic T cells that mainly involves subcutaneous adipose tissue rather than epidermis and dermis.It usually occurs in young and middle-aged population,and the etiology is currently unclear.Clinically,SPTCL is characterized by subcutaneous plaques,nodules,and skin ulcers with swell and ache,mainly presenting in limbs and trunk.SPTCL has been restricted to cases that expressα/βphenotype,whereas cases withγ/δphenotype are categorized to cutaneousγ/δ^+T cell lymphoma by WHO-EORTC classification.The standard treatment for SPTCL is not definite with a relatively good prognosis.The recent research progression of SPTCL is summarized in this review.