难治性癫痫患者认知水平影响因素分析

Factors Influencing Cognitive Level of the Cases with Refractory Epilepsy

目的探讨影响难治性癫痫患者认知水平的相关因素,以降低难治性癫痫患者认知功能障碍发生率。方法回顾性分析2016年6月至2019年6月在我院行不同治疗方式的58例难治性癫痫患者相关临床资料,采用SPSS22.0软件对影响患者认知水平的相关因素进行统计分析。结果Logistic回归分析结果显示,患者的年龄≥40岁、病程≥6年、发病频率超过4次/月、受教育年限≤12年、切除性手术治疗、单一用药、发作类型为复杂部分性发作是难治性癫痫患者认知水平的独立影响因素(P<0.05);Spearman相关性分析显示,年龄≥40岁、病程≥6年、发病频率超过4次/月、切除性手术治疗、单一用药、发作类型为复杂部分性发作与难治性癫痫患者认知水平呈正相关(P<0.05),受教育年限≤12年与难治性癫痫患者认知水平呈负相关(P<0.05)。结论明确影响因素并进行专项评估,针对影响难治性癫痫患者认知水平的相关因素进行积极防控,对提高患者的生存质量具有一定的重要意义。

Objective To explore the related factors influencing the cognitive level of the cases with refractory epi⁃lepsy so as to provide basis for decreasing the incidence of cognitive impairment.Methods A retrospective analysis was made to the clinical data of 58 cases with refractory epilepsy hospitalized during the period from June,2016 to June,2019 receiving various treatments and the related factors influencing the cognitive level of the cases were statistically analyzed with software SPSS22.0.Results Logistic regression analysis indicated that age≧40 years,disease course≧6 years,epilepsy attack more than 4 times a month,education years≦12 years,surgical resection,single medication and complex partial seizur were the independent factors influencing the cognitive level of the cases with refractory epilepsy(P<0.05);Spearman correlation analysis showed that age≧40 years,disease course≧6 years,epilepsy attack more than 4 times a month,surgical resection,single medication and complex partial seizur were in positive correlation with the cognitive level of the cases(P<0.05)while education years≦12 years was in negative correlation(P<0.05).Conclusions Definition of the influencing factors,special evaluation,active prevention and control targeted on the related factors in⁃fluencing the cognitive level of the cases with refractory epilepsy are of important significance in promoting the quality of life.