雾化吸入布地奈德治疗小儿毛细支气管炎的疗效及对E-ICR、PEF、FEV1水平的影响

Clinical effect of aerosol inhalation of budesonide in the treatment of children with bronchiolitis and its effect on E-ICR,PEF,FEV1

目的:探究雾化吸入布地奈德治疗小儿毛细支气管炎的疗效及对呼吸峰流速(PEF)、红细胞免疫复合物花环率(E-ICR)、1 s用力呼出量(FEV1)水平的影响。方法:2018年6月-2020年6月收治毛细支气管炎患儿64例,随机分为两组,各32例。两组均实施常规抗感染治疗,对照组给予消炎药治疗;观察组联合雾化吸入布地奈德治疗。比较两组临床疗效及对E-ICR、PEF、FEV1水平的影响。结果:观察组治疗后E-ICR水平显著低于对照组,PEF、FEV1水平均显著高于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率明显优于对照组,差异有统计学意义(P<0.05)。结论:雾化吸入布地奈德治疗小儿毛细支气管炎的效果显著,可以有效控制病情,改善阵发性喘息、气促、三凹征等相关临床症状。

Objective:To explore the effect of aerosol inhalation of budesonide in the treatment of children with bronchiolitis and its effect on E-ICR,PEF,FEV1.Methods:From June 2018 to June 2020,64 cases of children with bronchiolitis were enrolled,they were randomly divided into two groups with 32 cases in each group.Both groups were treated with conventional anti-infective therapy.The control group was treated with anti-inflammatory drugs,while the observation group was treated with combined atomization inhalation of budesonide.The clinical efficacy and effect on E-ICR,PEF,FEV1 level between the two groups were compared.Results:After treatment,the E-ICR level in the observation group was significantly lower than that in the control group,while the PEF,FEV1 levels were significantly higher than those in the control group,the differences were statistically significant(P<0.05).The total effective rate of treatment in the observation group was significantly better than that in the control group,the difference was statistically significant(P<0.05).Conclusion:The effect of inhalation of budesonide on bronchiolitis in children is remarkable,it can effectively control the condition and improve the clinical symptoms such as paroxysmal wheezing,shortness of breath and three depressions sign.