硫酸镁、酚妥拉明和硝苯地平联合治疗妊娠高血压的临床疗效分析

Analysis of the clinical efficacy of magnesium sulfate,phentolamine and nifedipine in the treatment of pregnancy induced hypertension syndrome

目的:研究硫酸镁、酚妥拉明和硝苯地平联合治疗妊娠高血压的效果。方法:2018年7月-2019年7月收治妊娠期高血压患者66例,随机分为两组,各33例。对照组给予硫酸镁治疗;研究组给予硫酸镁、酚妥拉明、硝苯地平联合治疗。比较两组临床疗效、并发症发生率及血压水平,评价两组患者治疗前后脑钠肽(BNP)和心功能指数。结果:研究组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。研究组并发症发生率低于对照组,差异有统计学意义(P<0.05)。研究组治疗后血压水平优于对照组,差异有统计学意义(P<0.05)。研究组治疗后BNP水平、心功能指数均优于对照组,差异有统计学意义(P<0.05)。结论:应用硫酸镁、硝苯地平及酚妥拉明联合治疗妊娠高血压效果显著,不但降低并发症发生率,还能保证产妇顺利生产,对血压水平及临床症状改善具有重要作用。

Objective:To study the effect of magnesium sulfate,phentolamine and nifedipine in the treatment of pregnancy-induced hypertension syndrome.Methods:From July 2018 to July 2019,66 cases of pregnancy induced hypertension syndrome were enrolled,they were randomly divided into two groups with 33 cases in each group.The control group was treated with magnesium sulfate,while the study group was treated with magnesium sulfate,phentolamine and nifedipine.The clinical efficacy,incidence of complications and blood pressure level between the two groups were compared.Results:The total effective rate of treatment in the study group was higher than that in the control group,the difference was statistically significant(P<0.05).The incidence of complications in the study group was lower than that in the control group,the difference was statistically significant(P<0.05).After treatment,the blood pressure level in the study group was better than that in the control group,the difference was statistically significant(P<0.05).After treatment,BNP index and heart function index of study group were better than those of control group,the difference was statistically significant(P<0.05).Conclusion:The combination of magnesium sulfate,nifedipine and phentolamine is more effective in treating pregnancy-induced hypertension syndrome,it can not only reduce the incidence of complications,but also ensure the smooth delivery of parturient and it plays an important role in the improvement of blood pressure level and clinical symptoms.