伸痛灵1号治疗急性期湿热蕴结型痛风性关节炎的临床观察

Clinical Observation on Treatment of Acute Gouty Arthritis of Damp-heat Accumulation Type with Shentongling No. 1

目的观察伸痛灵1号治疗急性期湿热蕴结型痛风性关节炎的临床疗效。方法将50例急性期湿热蕴结型痛风性关节炎按照随机数字表法分为2组,对照组25例予依托考昔片治疗,治疗组25例在对照组基础上加用伸痛灵1号方治疗。2组均治疗2周后统计疗效,比较2组治疗前及治疗1、2周后疼痛视觉模拟评分法(VAS)评分变化情况,比较2组治疗前及治疗1、2周后血清红细胞沉降率(ESR)、C反应蛋白(CRP)及尿酸(UA)水平变化情况。结论治疗组临床痊愈率40.00%(10/25),总有效率100%(25/25),对照组临床痊愈率8.00%(2/25),总有效率100%(25/25),2组总有效率相当,但治疗组临床痊愈率明显高于对照组(P<0.05)。2组治疗1、2周后疼痛VAS与本组治疗前比较均降低(P<0.05),且治疗组治疗1、2周后疼痛VAS均低于对照组(P<0.05)。2组治疗1、2周后血清CRP、ESR及UA水平与本组治疗前比较均降低(P<0.05),且治疗组治疗2周后CRP及UA水平均低于对照组(P<0.05)。结论伸痛灵1号方治疗急性期湿热蕴结型痛风性关节炎临床疗效确切,可明显缓解患者疼痛症状,降低CRP及UA水平,减轻局部组织炎症,提高临床痊愈率。

Objective To observe the clinical efficacy of Shentongling 1 in the treatment of acute gouty arthritis of damp-heat accumulation type. Methods A total of 50 cases of acute gouty arthritis with damp-heat accumulation were divided into two groups according to the random number table method. the control group were treated with etoricoxib tablets( n = 25),and the treatment group were treated with Shentongling No. 1 prescription on the basis of the control group( n = 25). The curative effects of the two groups were statistically analyzed after 2 weeks of treatment. The changes of VAS scores before treatment and 1 and 2 weeks after treatment in the two groups were compared. The changes of serum erythrocyte sedimentation rate( ESR),C-reactive protein( CRP) and uric acid( UA)levels before treatment and 1 and 2 weeks after treatment in the two groups were compared. Results The clinical cure rate of the treatment group was 40. 00%( 10/25),and the total effective rate was 100%( 25/25). The clinical cure rate of the control group was 8. 00%( 2/25),and the total effective rate was 100%( 25/25). The total effective rate of the two groups was consistent,but the clinical cure rate of the treatment group was significantly higher than that of the control group( P < 0. 05). The VAS scores of pain in the two groups after 1 and 2 weeks of treatment were lower than those before treatment( P < 0. 05),and the VAS scores of pain in the treatment group after 1 and 2 weeks of treatment were lower than those in the control group( P < 0. 05). The levels of CRP,ESR and UA in the two groups after 1 and 2 weeks of treatment were lower than those before treatment( P < 0. 05),and the levels of CRP and UA in the treatment group after 2 weeks of treatment were lower than those in the control group( P < 0. 05). Conclusion The clinical effect of Shentongling No. 1 prescription in the treatment of acute gouty arthritis of damp-heat accumulation type is exact,which can significantly relieve the pain symptoms of patients,promote pain regression,reduce CRP and UA levels,reduce local tissue inflammation and improve clinical cure rate.