益气活血法治疗慢传输型便秘临床观察及对患者血清P物质水平的影响

Clinical Observation on Treatment of Slow Transit Constipation with Qi-Invigorating and Blood-Activating therapy and Its Effect on Serum P Level

目的观察益气活血法治疗慢传输型便秘(STC)的临床疗效,以及对患者血清P物质(SP)水平的影响。方法将60例STC患者按照随机数字表法分为2组。治疗组30例予益气活血中药治疗,对照组30例予枸橼酸莫沙必利片治疗。2组均治疗10 d为1个疗程,治疗2个疗程后统计比较临床疗效,比较2组治疗前后便质、排便费力程度、排便频率、每次排便时间及腹胀评分变化情况,比较2组治疗前后便秘患者生活质量量表(PAC-QOL)生理状态、心理状态、担忧度、满意度评分及总分变化情况,比较2组治疗前后SP水平变化情况。结果治疗组总有效率93.3%(28/30),对照组总有效率73.3%(22/30),治疗组疗效优于对照组(P<0.05)。2组治疗后便质、排便费力程度、排便频率、每次排便时间及腹胀评分与本组治疗前比较均降低(P<0.05),且治疗组治疗后便质、排便费力程度及排便频率评分均低于对照组(P<0.05)。2组治疗后PAC-QOL生理状态、心理状态、满意度评分及总分与本组治疗前比较均降低(P<0.05),且治疗组治疗后PAC-QOL生理状态、心理状态、满意度评分及总分均低于对照组(P<0.05)。2组治疗后SP水平与本组治疗前比较均升高(P<0.05),且治疗组治疗后SP水平高于对照组(P<0.05)。结论益气活血法治疗STC临床疗效确切,可明显改善患者临床症状,提高生活质量,提高临床疗效,其作用机制可能与促进SP表达有关。

Objective To observe the clinical efficacy of Qi-Invigorating and Blood-Activating therapy in patients with slow transit constipation( STC) and its effect on serum substance P( SP) level. Methods Sixty STC patients were randomly divided into two groups. 30 cases in the treatment group were treated with Yiqi Huoxue Chinese medicine,and 30 cases in the control group were treated with mosapride citrate tablets. The two groups were treated for 10 days as a course of treatment,a total of 2 courses of treatment. The changes of defecation quality,defecation effort,defecation frequency,defecation time and abdominal distension score before treatment were compared between the two groups. The changes of physiological state,psychological state,anxiety,satisfaction score and total score of constipation patients ’ quality of life scale( PAC-QOL) before and after treatment were compared between the two groups. The changes of SP level before and after treatment were compared between the two groups. Results The total effective rate of the treatment group was 93. 3%( 28/30). The total effective rate of the control group was73. 3%( 22/30),and the curative effect of the treatment group was better than that of the control group( P < 0. 05).The defecation quality,defecation effort,defecation frequency,defecation time and abdominal distension scores of the two groups after treatment were lower than those before treatment( P < 0. 05),and the defecation quality,defecation effort and defecation frequency scores of the two groups after treatment were lower than those of the control group( P< 0. 05). The physiological state, psychological state,satisfaction score and total score of PAC-QOL in the two groups after treatment were lower than those before treatment( P < 0. 05),and the physiological state,psychological state,satisfaction score and total score of PAC-QOL in the two groups after treatment were lower than those in the control group( P < 0. 05). The SP level of the two groups after treatment was higher than that before treatment( P <0. 05),and the SP level after treatment was higher than that of the control group( P < 0. 05). Conclusion The Qi-Invigorating and Blood-Activating therapy of STC clinical curative effect is exact,which can significantly improve the clinical symptoms,improve the quality of life and improve the clinical efficacy. Its mechanism may be related to the promotion of SP expression.