干生物基质点微样技术及其在法医毒物学中的应用

The Dried Matrix Spot Micro-sampling Technique and its Application in Forensic Toxicology

干生物基质点(Dried Matrix Spot,DMS)微样技术是通过将微量生物液体(如血液、尿液和唾液等)收集于卡纸上并干燥后形成的样本采集和储存形式。干生物基质点微样技术较传统的采样方法有明显的优势:取样量小,样品处理简单,储存运输方便,目前已应用于流行病学调查、毒药物监测、药代动力学研究和毒代动力学研究等领域。通过对干生物基质的样品采集、储存稳定性、样品处理和分析方法等方面进行综述,以推动DMS微样技术在法医毒物学领域的拓展应用及鉴定技术的进步。

The dried matrix spot(DMS)micro-sampling technique is a form of sample collection and storage,which is formed by the collection of trace biological liquid(such as blood,urine and saliva)on the card and the drying.Compared with the traditional sampling method,DMS micro-sampling technique has obvious advantages:small sample size,simple sample processing,convenient storage and transportation,it has been applied in the field of epidemiological investigation,toxicological monitoring,pharmacokinetics and toxicokinetics.In order to promote the development and application of DMS micro-sampling technology in forensic toxicology and the progress of identification technology,this paper reviewed the methods of sample collection,storage stability,sample processing and analysis of DMS.