308 nm准分子激光+他克莫司治疗成人面部白癜风的效果

Effect of 308 nm excimer laser+Tacrolimus in the treatment of adult facial vitiligo

目的探讨308 nm准分子激光+他克莫司治疗成人面部白癜风的效果。方法选取2018年1月~2019年12月江西省萍乡市人民医院收治的70例面部白癜风患者,按随机投掷法分为参照组(n=35)和研究组(n=35)。参照组给予308 nm准分子激光照射治疗,研究组实施308 nm准分子激光+他克莫司治疗,比较两组的治疗总有效率、治疗前后细胞间黏附分子-1(ICAM-1)、黑素细胞刺激素(α-MSH)、白介素-17(IL-17)指标水平及不良反应发生率。结果研究组的治疗总有效率为94.29%,高于参照组的77.14%,差异有统计学意义(P<0.05);两组治疗前的ICAM-1、α-MSH、IL-17水平比较,差异无统计学意义(P>0.05);两组治疗后的ICAM-1、IL-17水平低于治疗前,α-MSH水平高于治疗前;治疗后研究组的ICAM-1、IL-17水平低于参照组,α-MSH水平高于参照组,差异均有统计学意义(P<0.05)。研究组的不良反应总发生率为11.43%,低于参照组的31.43%,差异有统计学意义(P<0.05)。结论308 nm准分子激光+他克莫司治疗成人面部白癜风的效果显著,且不良反应少,有临床推广价值。

Objective To explore the effect of 308 nm excimer laser+Tacrolimus in the treatment of adult facial vitiligo.Methods Seventy patients with facial vitiligo admitted to Pingxiang People′s Hospital,Jiangxi Province from January 2018 to December 2019 were selected and divided into reference group(n=35)and research group(n=35)according to the random throwing method.The reference group was treated with 308 nm excimer laser irradiation,and the research group was treated with 308 nm excimer laser+Tacrolimus,the total effective rate,intercellular adhesion molecule-1(ICAM-1),melanocyte stimulating hormone(α-MSH),interleukin-17(IL-17)indexes levels before and after treatment and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the research group was 94.29%,which was higher than 77.14%of the reference group,and the difference was statistically significant(P<0.05).There were no statistical differences in the levels of ICAM-1,α-MSH and IL-17 before treatment between the groups(P>0.05).After treatment,ICAM-1 and IL-17 levels of the two groups were lower than those before treatment,andα-MSH level was higher than that before treatment;after treatment,the levels of ICAM-1 and IL-17 in the research group were lower than those in the reference group,and the level ofα-MSH was higher than that in the reference group,the differences were statistically significant(P<0.05).The total adverse reaction rate in the research group was 11.43%,which was lower than that in the reference group(31.43%),the difference was statistically significant(P<0.05).Conclusion 308 nm excimer laser+Tacrolimus is effective in the treatment of adult facial vitiligo,and it has few adverse reactions,which has clinical promotion value.