羟氯喹治疗慢性光化性皮炎的临床效果

Clinical effect of Hydroxychloroquine in the treatment of chronic actinic dermatitis

目的探讨羟氯喹治疗慢性光化性皮炎的临床效果。方法选取2018年8月~2019年12月沈阳市第七人民医院收治的100例慢性光化性皮炎患者作为研究对象,按照随机信封法分为对照组(50例)与实验组(50例)。对照组用他可莫司软膏治疗,实验组采用羟氯喹治疗。比较两组的症状体征评分、皮肤病生活质量指数(DLQI)评分、临床治疗效果及不良反应发生情况。结果两组治疗前的症状体征评分比较,差异无统计学意义(P>0.05);两组治疗后的症状体征评分低于治疗前,且实验组治疗后的症状体征评分为(3.45±0.55)分,低于对照组的(5.65±0.80)分,差异均有统计学意义(P<0.05)。两组治疗前的DLQI评分比较,差异无统计学意义(P>0.05);两组治疗后的DLQI评分低于治疗前,且实验组的治疗后的DLQI评分为(6.50±0.80)分,低于对照组的(9.55±0.90)分,差异均有统计学意义(P<0.05)。实验组的治疗总有效率为96.00%,高于对照组的80.00%,实验组的不良反应总发生率为2.00%,低于对照组的14.00%,差异有统计学意义(P<0.05)。结论慢性光化性皮炎应用羟氯喹治疗的临床效果确切,能改善相关临床症状体征,提高皮肤病患者的生活质量,且不良反应发生率低,值得临床推广。

Objective To investigate the clinical effect of Hydroxychloroquine in the treatment of chronic actinic dermatitis.Methods A total of 100 patients with chronic actinic dermatitis admitted to Shenyang Seventh People′s Hospital,Liaoning Province from August 2018 to December 2019 were selected as the study objects.According to the random envelope method,they were divided into control group(50 cases)and experimental group(50 cases).The control group was treated with Tacrolimus Ointment and the experimental group was treated with Hydroxychloroquine.The symptoms and signs score,dermatology life quality index(DLQI)scale score,clinical treatment effect and adverse reactions were compared between the two groups.Results There was no significant difference the symptoms and signs score between the two groups before treatment(P>0.05).The scores of symptoms and signs of the two groups after treatment were lower than those before treatment,the score of symptoms and signs in the experimental group was(3.45±0.55)points,lower than that in the control group of(5.65±0.80)points,the differences were statistically significant(P<0.05).There was no significant difference in DLQI score between the two groups before treatment(P>0.05).The DLQI scores of the two groups after treatment were lower than those before treatment,the DLQI score of the experimental group was(6.50±0.80)points,lower than that of the control group of(9.55±0.90)points,the differences were statistically significant(P<0.05).The total effective rate of clinical treatment in the experimental group was 96.00%,higher than that of the control group 80.00%,the total incidence of adverse reactions in the experimental group was 2.00%,lower than that of the control group of 14.00%,the differences were statistically significant(P<0.05).Conclusion The clinical effect of Hydroxychloroquine in the treatment of chronic actinic dermatitis is accurate,it can improve the relevant clinical symptoms and signs,improve the quality of life of skin diseases,and the incidence of adverse reactions is low,it is worth clinical promotion.