洛铂联合紫杉醇诱导化疗对下咽癌患者保喉率与不良反应发生率的影响

Effect of Lobaplatin combined with Paclitaxel induction chemotherapy on larynx preservation rate and the incidence of adverse reactions in patients with hypopharyngeal cancer

目的探讨洛铂联合紫杉醇诱导化疗对下咽癌患者保喉率及不良反应发生率的影响。方法选取2017年11月~2020年1月大连大学附属中山医院收治的72例下咽癌患者作为研究对象。根据治疗方式不同分为对照组(37例)与观察组(35例)。对照组实施手术+放疗治疗,观察组实施手术+放疗+洛铂联合紫杉醇诱导化疗治疗。比较两组治疗总有效率、保喉率及不良反应发生情况。结果观察组治疗总有效率高于对照组,观察组保喉率高于对照组,差异有统计学意义(P<0.05);两组黏膜炎、中性粒细胞减少、恶心呕吐及皮疹等不良反应发生情况的比较,差异无统计学意义(P>0.05)。结论洛铂联合紫杉醇诱导化疗治疗下咽癌效果显著,能够提升保喉率,且具有一定安全性。

Objective To investigate the effect of Lobaplatin combined with Paclitaxel induction chemotherapy on the larynx preservation rate and the incidence of adverse reactions in patients with hypopharyngeal cancer.Methods A total of 72 patients with hypopharyngeal cancer admitted to Affiliated Zhongshan Hospital of Dalian University from November 2017 to January 2020 were selected as the research subjects.According to different treatment method,they were divided into the control group(37 cases)and the observation group(35 cases).In the control group,surgery+radiotherapy was used,and in the observation group,surgery+radiotherapy+Lobaplatin combined with Paclitaxel induction chemotherapy were adopted.The total effective rate,laryngeal preservation rate and the incidence of adverse reactions between the two groups were compared.Results The total effective rate of observation group was higher than that of control group,the larynx preservation rate in that observation group was high than that in the control group,the differences were statistically significant(P<0.05).Comparison of adverse reactions such as mucositis,neutropenia,nausea and vomiting and rash between the two groups,and the differences were not statistically significant(P>0.05).Conclusion Lobaplatin combined with Paclitaxel induction chemotherapy is effective in the treatment of hypopharyngeal cancer,which can increase the rate of laryngeal preservation in certain safety.