妊娠期糖尿病孕妇VEGF和SFRP-5与胰岛素抵抗的相关性分析

Correlation between VEGF and SFRP-5 and Insulin Resistance in pregnant women with gestational diabetes mellitus

目的分析妊娠期糖尿病(GDM)孕妇孕期血清血管内皮生长因子(VEGF)和分泌型卷曲相关蛋白5(SFRP-5)的表达及与其胰岛素抵抗(IR)的相关性。方法选取2019年1月至10月就诊于本院的3004例妊娠期孕妇的临床治疗资料,根据妊娠期糖尿病诊断标准择取妊娠期糖尿病孕妇279例作为研究组,另选取63例同时间段进行产检结果正常的孕妇作为对照组,观察两组孕妇的血清VEGF、SFRP-5及IR的表达情况,分析其相关性。结果研究组VEGF水平显著高于对照组,SFRP5蛋白和SFRP5 mRNA表达水平显著低于对照组,差异有统计学意义(P<0.05);研究组FPG、空腹胰岛素、HOMA-IR等指标水平含量均明显高于对照组,差异有统计学意义(P<0.05);经Spearman相关性分析,妊娠期糖尿病孕妇孕期的BMI指数与VEGF、SFRP5的表达无关,而FPG、空腹胰岛素、HOMA-IR与VEGF的表达呈正相关,与SFRP5的表达呈负相关(P<0.05)。结论妊娠期糖尿病孕妇VEGF水平越高,则会引起SFRP5水平降低,胰岛素抵抗增加。

Objective To analyze the expression of serum vascular endothelial growth factor(VEGF)and secreted frizzled-related protein 5(SFRP-5)of pregnant women with gstational diabetes mellitus(GDM)and the its correlation with insulin resistance(IR).Methods The clinical data of 3004 pregnant women treated in our hospital from January to October 2019 were selected.According to the diagnostic criteria of gestational diabetes,279 pregnant women with gestational diabetes mellitus were selected as the study group,and another 63 pregnant women with normal result of birth examination during the same period were selected as the control group.The serum VEGF,SFRP-5 levels and IR of pregnant women between the two groups were observed and their correlations were analyzed.Results The VEGF level in the study group was significantly higher than that in the control group,while the protein and mRNA levels of SFRP5 in the study group were significantly lower than those in the control group,the difference was statistically significant(P<0.05).The levels of FPG,fasting insulin,and HOMA-IR in the study group were significantly higher than those in the control group,the difference was statistically significant(P<0.05).According to the Spearman correlation analysis,the BMI index of pregnant women with gestational diabetes mellitus was not related to the expression of VEGF and SFRP5.FPG,fasting insulin,and HOMA-IR were positively correlated with VEGF expression and negatively correlated with SFRP5 expression(P<0.05).Conclusion The higher the level of VEGF in pregnant women with gestational diabetes,the lower the level of SFRP5 and the increase in insulin resistance.